Chronic myeloid leukemia is one of the most thoroughly studied and, undoubtedly, best understood neoplasms. There are about 4000 and 5000 new cases of CML every year in the USA. CML is a hematologic stem cell malignancy that typically evolves in 3 distinct clinical stages: chronic and accelerated phases and blast crisis. The chronic phase lasts several years and is characterized by accumulation...

BACKGROUND Chronic myelogenous leukemia (CML) is characterized by an initial chronic phase that invariably evolves to the more aggressive phase of blast crisis. Although the determinants of this transition are still unknown, it has been shown that the blast crisis is accompanied by genetic instability. MATERIALS AND METHODS The expression and activity of the error-prone DNA polymerase beta (p...

A 37-year-old man with no significant past family or personal medical history was admitted to the hospital for persistent eosinophilia detected during a routine check-up. He denied recent travel and was not a smoker, alcoholic, or drug addict. He did not have any history of allergic disease and was not exposed to any toxins or pesticides. Physical examination was normal. His complete blood exam...

Polysora rust (Southern Corn Rust) is a major disease of maize in tropical and subtropical region causing yield loss in excess of 45%. The loci governing resistance (Rpp9, RppQ and RppD) have been mapped to 10.01 bins on short arm of maize chromosome 10, which also has genes for common rust resistance like Rp1 and Rp5. With the publication of maize draft genomic sequence we tried to annotate th...

Blast, a disease caused by Magnaporthe oryzae, is major constraint for rice production worldwide. Introgression of durable blast resistance genes into high-yielding cultivars has been considered priority to control the disease. The Pik locus, located on chromosome 11, contains at least six important genes, but these have not widely employed in breeding since existing markers hardly satisfy curr...

Bacterial blight caused by Xanthomonas oryzae pv. oryzae and fungal blast caused by Magnaporthe grisea result in heavy production losses in rice, a main staple food for approximately 50% of the world's population. Application of host resistance to these pathogens is the most economical and environment-friendly approach to solve this problem. Quantitative trait loci (QTLs) controlling quantitati...

Physiological alterations, anxiety, and cognitive disorders are strongly associated with blast-induced traumatic brain injury (blast TBI), and are common symptoms in service personnel exposed to blasts. Since 2006, 25,000-30,000 new TBI cases are diagnosed annually in U.S. Service members; increasing evidence confirms that primary blast exposure causes diffuse axonal injury and is often accompa...

At last, a mouse model of the natural history of chronic myeloid leukemia (CML) has been elegantly engineered. CML is hardly a public health menace, occurring in only 1–2 per 100,000 people. Nonetheless, the disease is the " poster child " of genetically based diagnosis and treatment, as all cases of CML have the BCR-ABL trans-location, which is both a diagnostic marker of the disease and a tar...

Progress in understanding the abnormal regulation of hematopoiesis in chronic myelogenous leukemia (CML) would be facilitated if neoplastic cells, at all stages of the disease, could be studied in an animal model. In this report, we show that irradiated severe combined immunodeficient (SCID) mice can be transplanted with both normal (Philadelphia chromosome [Ph]-negative) and neoplastic (Ph+) c...

Chronic myeloid leukemia (CML) is typified by robust marrow and extramedullary myeloid cell production. In the absence of therapy or sometimes despite it, CML has a propensity to progress from a relatively well tolerated chronic phase to an almost uniformly fatal blast crisis phase. The discovery of the Philadelphia chromosome followed by identification of its BCR-ABL fusion gene product and th...