The secretory granules of adrenal medullary chromaffin cells synthesize, store and then liberate catecholamines by exocytosis after cell stimulation with acetylcholine, itself liberated from the splanchnic nerve (for review, see Viveros, 1975). Apart from adrenaline and noradrenaline, chromaffin granules contain a great number of molecules, essentially proteins, which are co-secreted with the c...

Incontinentia pigmenti (IP), is an X linked dominant disorder featuring blistering and hyperpigmentation along the lines of Blaschko. Genetically, a single large intragenic deletion spanning exons 4–10 IKBKG gene has been identified as cause IP in ∼80% all cases. Females with usually survive due to chromosome inactivation. However, nearly males typically die utero. Survival can be explained by ...

Lichen striatus is a self-limiting inflammatory dermatosis that is characteristically distributed along the Blaschko lines. It is usually seen in children although cases, with different histopathological features, have been reported in adults. In view of the characteristic clinical features of the disease in adults—with its papulovesicular aspect—it is known as blaschkitis. Subsequently, differ...

Three background issues motivate the present study. First, it has long been known that a special category of muscle, found in certain molluscs, can maintain tension for long periods after brief excitation with very little energy expenditure.'-3 Relaxation in these catch muscles may be separately initiated by inhibitory or relaxing neural input, by 5-hydroxytryptamine, by temperatures over 30'C,...

Vitiligo is an autoimmune disease characterized by depigmentation of the skin due to destruction of melanocytes. Interferons have been used for the treatment of chronic hepatitis C and some malignancies. We report interferon alpha-2a-induced vitiligo in a male patient with chronic active hepatitis C. All skin lesions disappeared completely without requiring therapy after discontinuation of inte...

Four related cows showed hairless streaks on various parts of the body with no correlation to the pigmentation pattern. The stripes occurred in a consistent pattern resembling the lines of Blaschko. The non-syndromic hairlessness phenotype observed occurred across three generations of a single family and was compatible with an X-linked mode of inheritance. Linkage analysis and subsequent whole ...

Recent studies in this laboratory of platelets from patients with rheumatoid arthritis and nonrheumatoid inflammatory states (1) have emphasized the importance of the transport system or systems concerned with absorption and release of serotonin by platelets. There is no agreement or definite knowledge concerning such transport mechanisms at present. Born, Ingram and Stacey (2) reported a posit...

About 60-70 % of the heterozygotes of X-linked hypohidrotic ectodermal dysplasia (XLHED) show some clinical manifestations of the disease. Dental abnormalities are key diagnostic features and can be best evaluated at a young age. Compared to controls, carriers have a significantly higher frequency of agenesis of permanent teeth with persistence of deciduous teeth, small teeth resulting in gaps ...

Wense (1938) has reported the isolation of crystalline adrenalin from larvae ("mealworms") of the beetle Tenebrio molitor. This observation, in addition to its interest from a comparative point of view, suggested the possibility of using the mealworm to study the biosynthesis of adrenalin, since in addition to the very high adrenalin content implied by Wense's work, it is known to possess a ver...

572 Indian Journal of Dermatology 2016; 61(5) 5. Chen JH, Wang KH, Hu CH, Chiu JS. Atypical angioma serpiginosum. Yonsei Med J 2008;49:509-13. 6. Ohnishi T, Nagayama T, Morita T, Miyazaki T, Okada H, Ohara K, et al. Angioma serpiginosum: A report of 2 cases identified using epiluminescence microscopy. Arch Dermatol 1999;135:1366-8. 7. Ghanadan A, Kamyab-Hesari K, Moslehi H, Abasi A. Dermoscopy ...