Sir, CTX-M-15 is an extended-spectrum b-lactamase (ESBL) extensively reported in humans, and in particular in Escherichia coli clones of sequence types (STs) ST131 and ST405. The blaCTX-M-15 gene has also become prevalent in Klebsiella pneumoniae, causing outbreaks in hospitals worldwide. – 4 In animals, a highly prevalent ESBL gene is the blaCTX-M-1 gene, with the blaCTX-M-15 gene also being f...

Following the introduction of expanded spectrum cephalosporins into clinical usage, the production of extended-spectrum -lactamases (ESBLs) by members of the Enterobacteriaceae has been documented (5, 6). One of these ESBLs, CTX-M, has become the predominant ESBL type in eastern Asia, South America, and Eastern Europe. And it also exhibits an overall preferential hydrolysis of cefotaxime and ce...

We report the genetic characterization of 15 Klebsiella pneumoniae (KP) and 4 isolates of K. oxytoca (KO) from clinical cases in dogs and cats and showing extended-spectrum cephalosporin (ESC) resistance. Extended spectrum beta-lactamase (ESBL) and AmpC genes, plasmid-mediated quinolone resistance (PMQR) and co-resistances were investigated. Among KP isolates, ST101 clone was predominant (8/15,...

The aim of this study was to determine the prevalence of extended-spectrum b-lactamase (ESBL)producing Klebsiella pneumoniae isolated from urinary tract and bloodstream infections in a rural hospital in Manhiça, Mozambique. ESBLs were investigated among ceftriaxone-non-susceptible K. pneumoniae clinical isolates recovered between 2004 and 2009. Characterisation of blaCTX-M, blaSHV, blaOXA and b...

Objective(s) Different types of extended spectrum beta-lactamases (ESBLs) are encountered in the clinical settings worldwide. There are a few studies regarding the prevalence of ESBL genes among Klebsiella pneumoniae isolates at Tehran especially those of blaPER and blaCTX. The aim of this study was to determine the prevalence of blaSHV, blaTEM ,blaPER and blaCTX genes among clinical K. pneumon...

This study aimed to determine the prevalence of fecal carriage of extended spectrum β-lactamase (ESBL) and/or plasmidic AmpC β-lactamase (pAmpC) producing Escherichia coli among dogs (n=428) in Turkey. Polymerase chain reaction (PCR) and sequencing were used to characterize genes encoding β-lactamase and plasmid mediated quinolone resistance (PMQR). Antimicrobial susceptibility testing and PCRs...

In117, an Unusual In0-Like Class 1 Integron Containing CR1 and blaCTX-M-2 and Associated with a Tn21-Like Element Aránzazu Valverde, Rafael Cantón, Juan Carlos Galán, Patrice Nordmann, Fernando Baquero, and Teresa M. Coque* Hospital Universitario Ramón y Cajal, IMSALUD, Madrid, Spain, and Service de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de M...

Background: Community-acquired infections by multidrug-resistant (MDR), extended-spectrum β-lactamase (ESBL) producing Klebsiella species (Klebsiella spp.) is of major concern worldwide. Antibiotic resistance, production of extended-spectrum β-lactamases (ESBLs), and carbapenemases, as well as the presence of classes 1, 2, and 3 integrons in outpatient isolates of Klebsiella collected from Yazd...