OBJECTIVES Some propofol emulsion formulations contain EDTA or sodium metabisulfite to inhibit microbe growth on extrinsic contamination. EDTA is not known to react with propofol formulation components; however, sulfite has been shown to support some oxidation processes and may react with propofol. This study compared the oxidation of propofol and the formation of free radicals by electron para...

BACKGROUND The effectiveness of inhaled aerosolized antibiotics is limited by poor ventilation of infected airways. Pulmonary delivery of antibiotics emulsified within liquid perfluorocarbon [antibacterial perfluorocarbon ventilation (APV)] may solve this problem through better airway penetration and improved spatial uniformity. However, little work has been done to explore emulsion formulation...

ISSN 1420-3049 www.mdpi.comjournalmolecules. Component of parenteral emulsions for drug and vaccine delivery. Modified paco alcazar pdf release, and cell uptake of drugs, adjuvants, and vaccines. A liquid at room temperature, squalene oil has a viscosity of 11 cP, a.The authors hypothesized that a lipid emulsion containing medium-chain triglycerides MCTs. An emulsion of MCTs and soybean, olive,...

The tributyrin lipid emulsion was proved to be able to bind to low-density lipoprotein (LDL) in vitro. The aim of this study was to investigate the pharmacokinetics of the emulsion in vivo and the cellular activity in vitro. The pharmacokinetics of tributyrin and its metabolite, butyrate, was evaluated in male Wistar rats after administration with pure tributyrin or tributyrin emulsion. After o...

The percentage removal of phenol from aqueous solution by emulsion liquid membrane and emulsion leakage was investigated experimentally for various parameters such as membrane:internal phase ratio, membrane:external phase ratio, emulsification speed, emulsification time, carrier concentration, surfactant concentration and internal agent concentration. These parameters strongly influence the per...

To advance emulsion droplet technology, we synthesize functional derivatives of Pluronic F127 that can simultaneously act as surfactants and as reactive sites for droplet surface decoration. The amine-, carboxyl-, N-hydroxysuccinimide ester-, maleimide- and biotin-terminated Pluronic F127 allows ligand immobilization on single-emulsion or double-emulsion droplets via electrostatic adsorption, c...

Chromatin insulators organize the genome into distinct transcriptional domains and contribute to cell type-specific chromatin organization. However, factors regulating tissue-specific insulator function have not yet been discovered. Here we identify the RNA recognition motif-containing protein Shep as a direct interactor of two individual components of the gypsy insulator complex in Drosophila....

In the paper the novel soft magnetic composite system is investigated. A ferrofluid emulsion studied demonstrates the strong magnetic properties which are atypical for commonly known emulsions. Interaction of ferrofluid emulsions with a magnetic field is considered. Structural transformations in these media, such as deformation of emulsion microdroplets and emulsion inversion, are studied. The ...

Herein it was found that CO(2) could trigger an O/W to W/O emulsion inversion via a W/O/W nanoemulsion. In comparison with the conventionally used liquid or solid additives, the unusual advantage of this method is that the emulsion morphologies can be switched reversibly by the control of CO(2) pressure. Besides, CO(2) can be easily removed by depressurization and thus no extra separation proce...

The anticonvulsive properties of pregnanolone (as an emulsion) were evaluated in mice and compared with similar properties of Althesin and thiopentone. Pregnanolone emulsion was found to antagonize convulsions induced by the GABA antagonists pentetrazole, bicuculline and picrotoxin and by the specific glycine receptor antagonist, strychnine. The drug was effective in all four convulsive tests a...