School of Computer Science, Raymond and Beverly Sackler Faculty of Exact Sciences, Tel Aviv University, Tel Aviv 69978, Israel Department of Biopharmaceutical Sciences and Pharmaceutical Chemistry, and California Institute for Quantitative Biomedical Research, University of California at San Francisco, San Francisco, CA 94158, USA School of Crystallography, Birkbeck College University of London...

What’s in your product? Come hear the latest advances in the field of biopharmaceutical HCP Testing ● Rare Reagents: Multiple Case Studies on how to develop your rare reagents, including selection of null cell lines, developing immunization strategies and assessing the specificity of your antibodies, characterization of antibodies and standards by 2-D Gels, western blots, and immunofractionation

The imminent patent expiration of many biopharmaceutical products will produce the possibility for generic versions of these therapeutic agents (i.e. biosimilars). However, there are a number of issues that will make approval of biosimilars much more complicated than the approval of generic equivalents of conventional pharmaceuticals. These issues centre on the intrinsic complexity of biopharma...

The clarification of biological feed stocks during the production of biopharmaceutical proteins is challenging when large quantities of particles must be removed, e.g., when processing crude plant extracts. Single-use depth filters are often preferred for clarification because they are simple to integrate and have a good safety profile. However, the combination of filter layers must be optimize...

Biopharmaceutical companies are critical in developing vaccines, treatments, and diagnostics for COVID-19. Thus, understanding the contagion effects of their stock market can have important economic implications, especially context global financial markets. Due to COVID-19 pandemic, biopharmaceutical companies’ markets may experienced sudden volatility risk changes, which had spillover on other...

BACKGROUND Baker's yeast Saccharomyces cerevisiae is a proven host for the commercial production of recombinant biopharmaceutical proteins. For the manufacture of heterologous proteins with activities deleterious to the host it can be desirable to minimise production during the growth phase and induce production late in the exponential phase. Protein expression by regulated promoter systems off...

Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.

Modelling biopharmaceutical manufacture: Design and implementation of SimBiopharma Suzanne S. Farid a,∗, John Washbrook b, Nigel J. Titchener-Hooker a a The Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, UK b Department of Computer Science, University College London, Gower Street, London WC1E 6BT, UK

A recent meeting titled "Conserved Mechanisms of Stem Cell Control and Regeneration" was held at the Biopharmaceutical Technology Center Institute (BTCI) in Madison, Wisconsin. The diversity of stem cells and biological contexts discussed highlight the field's rapid progress in deciphering the molecular basis of stem cell functions and emphasize the challenges facing the future exploitation of ...

Dispersions in transcutol/isopropyl myristate make C60 fullerene molecules suitable for transdermal delivery. We found that C60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropyl myristate without harsh organic solvents ...