abstractpyrimidine nucleosides are constituents of fundamental structure of the cells. there has been considerable attentions in the chemistry of pyrimidine derivatives due to having a wide range of biological activities such as antiviral, anti-malarial agents, cytostatic, antithelemintic, antibacterial, adenosine receptor ligands, anti-cancer agents, compounds targeting delayed-type hypersensi...

Novel analytic methods are required to assimilate the large volumes of structural and bioassay data generated by combinatorial chemistry and high-throughput screening programmes in the pharmaceutical and agrochemical industries. Recent work in visualisation and data mining has been used to develop structure--activity relationships from such chemical-biological datasets.

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering Kyoto University, Katsura, Kyoto 615-8510, Japan. Present address: Department of Chemistry, Graduate School of Science, Tohoku University, Aramaki-aza Aoba 6-3, Aoba-ku, Sendai 980-8578, Japan. Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency, 5 Sanbancho, ...

Y. Tokita,†,‡,§ J. Hasegawa,† and H. Nakatsuji*,†,‡,| Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto UniVersity, Sakyo-ku, Kyoto 606-01, Japan, The Institute for Fundamental Chemistry, 34-4 Takano Nishi-Hiraki-cho, Sakyo-ku, Kyoto 606, Japan, Research Center, Denki Kagaku Kogyo Co., Ltd., 3-5-1 Asahimachi, Machida-shi Tokyo 194, Japan, and Department o...

BRUCEI AND LEISHMANIA MAJOR Han B. Ong, Natasha Sienkiewicz, Susan Wyllie and Alan H. Fairlamb From the Division of Biological Chemistry & Drug Discovery, College of Life Sciences, University of Dundee, Wellcome Trust Biocentre, Dundee, Scotland DD1 5EH, UK Running title: Essential role of T. brucei PTR1 in recycling dihydropterins Adress correspondence to Professor Alan H. Fairlamb, Division o...