Authors of papers to the bioinformatics approach tbo analyse the nucleotide and amino acid sequence of alpha synuclein nucleotide and amino acid. including as the character of physical and hydrophobicity, seondary structure prediction domains, prediction of the conserved domains and phylogenetic analysis. The results showed the α-synuclein encode a deduced 1462amino acid, had a predicted molecu...

Motivation Motif identification and analyses are important and have been long-standing computational problems in bioinformatics. Substantial efforts have been made in this field during the past several decades. However, the lack of intuitive and integrative web servers impedes the progress of making effective use of emerging algorithms and tools. Results Here we present an integrated web serv...

The availability of whole genome information of several model organisms offers the possibility to perform analyses of protein families to decipher accurate protein function prediction. Association of gene products to pre-existing families is a popular approach to the prediction of function. However, despite the availability of huge amounts of valuable protein sequence information, nearly half o...

The Cyanophages are the phages infecting cyanobacteria. They are potential agents for the horizontal gene transfer. The complete genome of 10 known Cyanophages deciphered the presence of various gene sequences for hypothetical proteins whose functions are not yet understood. Our attempt is to predict the structure and function of these hypothetical proteins by the application of computational m...

Optimisation problems pervade structural bioinformatics. In this review, we describe recent work addressing a selection of bioinformatics challenges. We begin with a discussion of research into protein structure comparison, and highlight the utility of Kolmogorov complexity as a measure of structural similarity. We then turn to research into de novo protein structure prediction, in which struct...

Background B cell epitopes corresponding to interaction zones between proteins and immune system are a mean to explore intrinsic features of proteins linked to allergenicity. The project PREDEXPITOPE was funded by the French National Research Agency to develop a bioinformatics strategy for prediction of B cell epitopes of allergens. The objective was to distinguish epitopic from non epitopic ar...

Background: Toll-like receptors (TLRs) detect diverse pathogen-associated molecular patterns and play a critical role in the innate immune response. Hosts should activate TLR-signaling pathways to eliminate invading pathogens. However, excessive activation of these pathways may interrupt immune homeostasis, leading to several diseases. Therefore precise regulation of TLR-signaling pathways is e...

human cytomegalovirus is one of the most common pathogenic viruses all over the world. in congenital infection leads to neurologic severe disorders and even death of fetus and in individuals with immunosuppression may also cause severe clinical symptoms. multiple evidence indicate that among several strategies, epitope-based vaccine (evs) that can induce both humoral and cellular immunity respo...

PlantGDB (http://www.plantgdb.org/) is a database of molecular sequence data for all plant species with significant sequencing efforts. The database organizes EST sequences into contigs that represent tentative unique genes. Contigs are annotated and, whenever possible, linked to their respective genomic DNA. Genome sequence fragments are assembled similarly. The goal of the PlantGDB web site i...

Thomas Hamelryck, John Haslett, Kanti Mardia, John T. Kent, Jan Valentin, Jes Frellsen, Jesper Ferkinghoff-Borg The Bioinformatics center, University of Copenhagen, Denmark School of Computer Science and Statistics,Trinity College, Dublin Department of Statistics, School of Mathematics, The University of Leeds, UK Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby,...