Munc13-1 is an essential component of synaptic vesicle releasing machinery. Three rat Munc13-1 constructs were rationally designed based on homology and function, overexpressed in Escherichia coli, and purified to homogeneity with a final yield higher than 2 microg/ml of cell culture. The purified Munc13-1 recombinant proteins had distinct oligomeric states, monodispersity and homogeneity prope...

202 On investigation, routine blood, urine examination and biochemical parameters were normal. Erythrocyte sedimentation rate (ESR) was 50 mm at first hour. Blood VDRL test was reactive (1:64). Cerebro spinal fluid VDRL test was non-reactive. CD4 cell count was 271 cells/mm3. Other investigations were normal. Skin biopsy and histopathology revealed endarteritis obliterans and few granulomas. Be...

We experienced a 65-year-old woman with Sjögren's syndrome who presented with acute renal failure, hypergammaglobulinemia with monoclonal gammopathy, and hypocomplementemia. She improved with steroid pulse therapy (methylprednisolone 0.5 g/day for 3 days). This patient had also sensorineural hearing loss, symmetric sensory polyneuropathy of legs, and interstitial lung disease. Ten months after ...

The adrenal cortical hormone 17-hydroxy-11dehydrocorticosterone, hereinafter called " compound E" (Mason and others, 1938; Reichstein and Shoppee, 1943) has been administered to fourteen patients with severe or moderately severe rheumatoid arthritis. In each case improvement in clinical features and in sedimentation rates began to occur within a few days. When administration of the hormone was ...

Polychlorinated biphenyls exposure damages the rat liver cells. Hematological parameters such as hemoglobin, packed cell volume, red-blood cells, white-blood cells, neutrophils, platelet counts, and RBC indices were significantly decreased. Polymorphs, eosinophil counts, and erythrocyte sedimentation rate were significantly increased. Serum liver enzymes such as aspartate transaminase, alanine ...

A 16-year-old girl was admitted to the hospital suffering from severe back pain, night sweats, and weight loss for 3 weeks. On physical examination, she had multiple lymphadenopathies in the cervical, axillary, and inguinal regions. There was no organomegaly. Peripheral blood smear revealed no blasts or atypical cells. The erythrocyte sedimentation rate was 102 mm/h. All biochemical test result...

A structural and biochemical study is presented concerning the agglutination of gametic flagella, the initial step in the mating reaction of Chlamydomonas reinhardtii. An alteration in the distribution of the intramembranous particles revealed by freeze-fracturing of flagella membranes is shown to accompany gametic differentiation in both mating types. The isolation and electrophoretic analysis...

Therapeutic efficacy of certain poly herbal formulations and probiotics along with heterologous cud transplantation was evaluated in simple indigestion in buffaloes. A total of 18 buffaloes suffering from simple indigestion were treated with Suruchi bolus (10 g twice daily) or Gastricare powder (15g twice daily) or Yeasacc bolus with heterologous cud from healthy sheep. Clinical examination and...

An 8-year-old girl presented with left ankle pain and limping for 1 month. There was no history of trauma or febrile illness. Her medical history was unremarkable, and there was no family history of rheumatism. Physical examination revealed mild soft tissue swelling and tenderness over the lateral aspect of the ankle and heel. No skin change, local warmth or focal mass was evident, but the rang...

Two children with prolidase deficiency, an inborn error of proline metabolism, developed clinical and immunological abnormalities consistent with a diagnosis of systemic lupus erythematosus (SLE). The first child died from septicaemia, and SLE was only diagnosed during his terminal illness. As a result of this diagnosis his cousin, who was already known to have prolidase deficiency, was investi...