Catabolism of Trp and Lys produces alpha-ketoadipic acid as an intermediary metabolite. An alternate pathway of Trp turnover leads to NAD synthesis. We hypothesized that excess Lys might improve the conversion of Trp to niacin by causing a buildup of alpha-ketoadipic acid, thereby endproduct inhibiting the main Trp catabolic pathway and resulting in more niacin synthesis from Trp. Six bioassays...

BACKGROUND Natural estrogen decline leads to vasomotor symptoms (VMS). Hormone therapy alleviates symptoms but increases cancer risk. Effective treatments against VMS with minimal cancer risks are needed. We investigate the effects of a highly bioavailable aglycone rich Red Clover isoflavone treatment to alleviate existing menopausal VMS, assessed for the first time by 24hour ambulatory skin co...

BACKGROUND Evidence is lacking to recommend one diet over another when treating polycystic ovary syndrome (PCOS). OBJECTIVES To obtain preliminary data, comparing the impact of a low-glycaemic load (LGL) vs. low-fat (LF) diet on biochemical hyperandrogenism in overweight and obese adolescents with PCOS. To ascertain feasibility of recruiting study participants, in partnership with an adolesce...

OBJECTIVE We compared the renal and systemic vascular (renovascular) response to a reduction of bioavailable nitric oxide (NO) in type 2 diabetic patients without nephropathy and of African and Caucasian heritage. RESEARCH DESIGN AND METHODS Under euglycemic conditions, renal blood flow was determined by a constant infusion of paraminohippurate and changes in blood pressure and renal vascular...

BACKGROUND Hypogonadism is frequently diagnosed based on total testosterone (TT) levels alone. However, 99% of testosterone is bound to the sex hormone-binding globulin (SHBG) with only 1% free testosterone. Alternative assessment methods consist of assay of free testosterone (FT) or bioavailable testosterone (BT) by equilibrium dialysis, calculation of FT and BT through the Vermeulen equations...

Communicated by Joseph DePinto Harmful algal blooms (HABs) have increased in frequency and magnitude in western Lake Erie and spring phosphorus (P) load was shown to be a key driver of bloom intensity. A recently developed Bayesian hierarchical model that predicts peak bloom size as a function of Maumee River phosphorus load suggested an apparent increased susceptibility of the lake to HABs. We...

INTRODUCTION AND OBJECTIVES The best indicators to the diagnosis of hypogonadism are free and bioavailable testosterone circulating levels. Free and bioavailable testosterone measurements are complex. However, simple kits for direct measurement of free testosterone by analog immunoassay are available. We examined the utility of an enzymoimmunoassay kit for free testosterone measurement. MATER...

Urban soil pollution has become a major concern in megacities around the world. Due to their non-degradable characteristic, toxic metals are among the most notorious pollutants. In this study determination of total and bioavailable fraction of toxic metals Ni, Cu, Cr, Zn, Co, Cd, Pb and Mn, in surface soils of district 16th in Tehran municipality is considered. Furthermore, metals uptake potent...

A new microwave-assisted hybrid heating process allows providing thermochemical treatment of sewage sludge ash, with the formation bioavailable phosphate compounds.