The unabated silicon technology scaling makes design and manufacturing increasingly harder in nanometer VLSI. On one hand, major design objectives such as timing, power, and noise are often conflicting with each other in modern designs with multi-million gates, resulting in complex design closure. On the other hand, design closure no longer guarantees historical yield norm, requiring ever-chall...

Innovative engineered nanomaterials are at the leading edge of rapidly emerging fields of nanobiotechnology and nanomedicine. Meticulous synthesis, unique physicochemical properties, manifestation of chemical or biological moieties on the surface of materials make engineered nanostructures suitable for a variety of biomedical applications. Besides, tailored nanomaterials exhibit entirely novel ...

BACKGROUND The sensitivity and selectivity of traditional methods limits ultramicro detection of proteins. Bio-barcode amplification detection methods based on nanotechnology enables ultramicro detection of protein. However, bio-barcode amplification detection depends on the oligonucleotides being fixed on a glass chip. It also requires specialized equipment, which limits its application. We in...

Nano-sized hydroxyapatite (n-HA) is considered as a bio-active material, which is often mixed into bone implant material, polyetheretherketone (PEEK). To reveal the global protein expression modulations of osteoblast in response to direct contact with the PEEK composite containing high level (40%) nano-sized hydroxyapatite (n-HA/PEEK) and explain its comprehensive bio-effects, quantitative prot...

A recent projection noted that over 7 million jobs will be created in the nano and bio-related field world wide by 2015. The expected growth of such jobs suggests a critical need to prepare and train the workforce for these emerging fields. This paper describes a collaborative approach between three universities to integrate nano/bio technology into the mechanical engineering (ME) undergraduate...

Background: Although microemulsion-based nanoparticles (MEs) may be useful for drug delivery or scavenging, these benefits must be balanced against potential nanotoxicological effects in biological tissue (bio-nano interface). We investigated the actions of assembled MEs and their individual components at the bio-nano interface of thrombosis and hemolysis in human blood. Methods: Oil-in-water M...

Although many breast and lung cancers overexpress human epidermal growth factor receptor-2 (HER-2), no methods currently exist for effective and early detection of HER-2-positive cancers. To address this issue, we designed and synthesized dendrimer-based novel nano-imaging agents that contain gold nanoparticles (AuNPs) and gadolinium (Gd), conjugated with the humanized anti-HER-2 antibody (Herc...

The field of biotechnology presents us with a great chance to use many organisms, such as mushrooms, find suitable solutions for issues that include the accumulation agro-wastes in environment. green mushrooms (Pleurotus ostreatus L.) includes myco-remediation polluted soil and water well bio-fermentation. circular economy approach could be effectively achieved by using oyster L.), which substr...

Bone plates are essential for bone fracture healing because they modify the biomechanical microenvironment at site to provide necessary mechanical fixation fragments. This paper addresses use of composite in long-bone fractures such as transverse femur. However, stress shielding due metal can be reduced by designing implants with Bio-composites that involve Ultra high molecular polyethylene rei...

chemical vapor deposition was employed to synthesize carbon nanotubes with ni-loaded mcm-41 and mcm-48 as catalysts and acetylene as precursor at 750°c. mesoporous ni mcm-41 and ni mcm-48 molecular sieves were synthesized by a hydrothermal method and were characterized by xrd and n2 adsorption isotherm. the catalytically synthesized carbon materials were characterized with raman spectroscopy, n...