HCV-induced hepatitis is one of the most debilitating diseases. The limited number of anti-HCV drugs and drug-resistance necessitate developing of new scaffolds with different mode of actions. HCV non-structural protein 5B (NS5B) is an attractive target for development of novel inhibitors of HCV replication. In this paper, new N'-arylidene-6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-3-carbohydrazi...

Hardwood KP bleaching effluents, before (influent) and after (effluent) biological treatment, were characterized and compared to identify the main bio-recalcitrant organic compounds in the effluent. The results indicate that biological treatment reduces CODcr and BOD5 by 67% and 88%, respectively. However, various bio-recalcitrant organic compounds were still retained in the biologically-treate...

Background It has been previously shown that supplementation with a commercial food-based bio-active peptide product (Bio-GroTM) may improve resistance training capacity and enhance recovery between repeated bouts of strenuous exercise. It has been suggested that enhanced workout capacity during training sessions and improved recovery from exercise may enhance chronic training adaptions, such a...

The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. The structures of the compounds were confirmed by spectral methods and elemental analysis. The potassium channel opening effects of the compounds were determined o...

a series of novel 2-aminopyrimidine and 2-substituted-4,6-diaminopyrimidine derivatives have been synthesized and their anti platelet aggregation activities were assessed against adp and arachidonic acid- induced platelet aggregation in human plasma using light transmission aggregometry. none of the compounds showed satisfactory activity against the aggregation induced by adp. however, satisfac...

Bio-oil includes significant levels of oxygenate molecules, which might induce component instability and reduce its physicochemical qualities. To counteract this, the must undergo a hydrodeoxygenation (HDO) reaction. Due to presence acidic active sites, zeolites have been shown high hydrogenation deoxygenation capabilities. However, natural zeolite has large number impurities low acidity densit...

walnut is a hardwood tree which covers a wide area of the plantation forest and gardens. the objective of this study was the separation and identification of compounds produced from pyrolysis of walnut wood at fixed bed reactor under an inert gas atmosphere (nitrogen) at 350 oc for 20 minutes. the separation and identification of compounds from bio-oil treated with n,o-bis (tri methyl sailil) t...

The present study reports a microwave-assisted method for the synthesis of twelve novel tricyclic 1,4-dihydropyridine derivatives in which dimethyl-substituted cyclohexane and / or tetrahydrothiophene rings are fused to the DHP ring. The structures of the compounds were confirmed by spectral methods and elemental analysis. The potassium channel opening effects of the compounds were determined o...

Indonesia is the world's largest palm oil producer with a land area of 14.3 million as 2019. With this area, it will produce biomass in form replanted stems, midribs, empty bunches (TKKS), shells and fruit fibers. Biomass waste, including solid has potential to be used raw material for renewable energy or bioenergy. This study aims utilize plantation waste into bio briquettes. The materials wer...