نتایج جستجو برای: bim
تعداد نتایج: 6444 فیلتر نتایج به سال:
IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms.
Insulin-like growth factor-1 (IGF-1) is an important growth and survival factor in multiple myeloma (MM). Here, we demonstrate that IGF-1 induces significant down-regulation of the proapoptotic BH3-only protein Bim in MM cells. Reduced Bim levels by RNA interference (RNAi) protected cells from drug-induced cell death. The IGF-1-mediated down-regulation of Bim was the result of (1) reduced trans...
Biologically inspired model (BIM) for image recognition is a robust computational architecture, which has attracted widespread attention. BIM can be described as a four-layer structure based on the mechanisms of the visual cortex. Although the performance of BIM for image recognition is robust, it takes the randomly selected ways for the patch selection, which is sightless, and results in heavy...
Distinct proteins complexed with somatostatin and the somatostatin analogue BIM-23014C were revealed in human breast cancer cells using the cross-linking assay. One BIM-23014C-specific complex (Mr 57,000) was observed in MCF-7 (monolayer, nodule, and tumor) and T47D. Growth inhibition of MCF-7 tumor xenografts by BIM-23014C was dose related in the 6-day subrenal capsule assay. Three complexes (...
Building Information Modelling is further globalising Architecture, Engineering and Construction (AEC) professional partnerships. However, little is known on the effect of cultural and human factors on BIM enabled visualisation applications. This desktop study examined the extant literature on factors relating to application of BIM enabled visualisation technologies as a process that can improv...
Building information modeling (BIM) is significantly influencing the way in which building and engineering projects are being planned, designed, constructed and maintained. It has been widely advocated that BIM will significantly reduce design and construction errors as well improve project cost and schedule. There is a lack of empirical research about the underlying ‘latent conditions’ contrib...
The title compound, [Cu(2)(C(9)H(12)N(4))(3)](CF(3)SO(3))(2), contains two Cu(I) ions, three bis-(1-methyl-imidazol-2-yl)methane (Me(2)BIM) ligands, and two trifluoromethanesulfonate anions in the asymmetric unit. Each Cu(I) ion has a distorted trigonal-planar geometry and is coordinated by two N atoms from the Me(2)BIM ligand and another N atom from the Me(2)BIM that acts as a bridging ligand,...
BIM has been widely used in project management, but on the whole the applications have been scattered and the BIM models have not been deployed throughout the whole project life-cycle. Each participant builds their own BIM, so there is a major problem in how to integrate these dynamic and fragmented data together. In order to solve this problem, this paper focuses on BIMbased life-cycle informa...
Repeatedly activated T helper 1 (Th1) cells present during chronic inflammation can efficiently adapt to the inflammatory milieu, for example, by expressing the transcription factor Twist1, which limits the immunopathology caused by Th1 cells. Here, we show that in repeatedly activated murine Th1 cells, Twist1 and T-bet induce expression of microRNA-148a (miR-148a). miR-148a regulates expressio...
java is an object-oriented program that has abundant open-source libraries for application development and 3d model rendering. spatial database is the database that can efficiently store and manage geographic information data though various spatial data management techniques. this paper explores the rationale of coupling java with spatial database to develop an effective platform for future bui...
Apoptosis is critical for the development and maintenance of the immune system. The proapoptotic Bcl-2 family member Bim is important for normal immune system homeostasis. Although previous experiments have shown that Bim is critical for the apoptosis of antigen-specific CD8(+) T cells during acute viral infection, the role of Bim during chronic viral infection is unclear. Using lymphocytic cho...
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