BACKGROUND Atazanavir plus raltegravir 300/400 mg twice daily is being explored as a ritonavir- and nucleoside-sparing treatment strategy. The pharmacokinetics and safety of this combination in healthy individuals were evaluated. METHODS A total of 22 healthy individuals received raltegravir 400 mg on days 1-5, atazanavir 300 mg on days 6-12 and atazanavir plus raltegravir 300/400 mg on days ...

The objective of the present work is to study the casting characteristics of various A1-Li alloys, which include fluidity and strengths of the alloys and their interaction with cast molds. Materials investigated are Al-Li-Mg and Al-Li-Cu-Mg alloys with Li content of 2.5 wt%. The results show that sand molds with resin binders are good for A1-Li casting. Ceramic coatings can further reduce the m...

BACKGROUND Reducing low-density lipoprotein cholesterol (LDL-C) is the primary goal of therapy in patients with hypercholesterolemia and coronary heart disease (CHD). METHODS This double blind placebo-controlled study enrolled patients 18 to 75 years of age with primary hypercholesterolemia and established CHD who were taking a stable daily dose of simvastatin 20 mg. Patients were randomized ...

There is variability in the Mg isotopic composition that is a reflection of the widespread heterogeneity in the isotopic composition of the elements in the solar system at approximately 100 ppm. Measurements on a single calcium-aluminum-rich inclusion (CAI) gave a good correlation of Mg ⁄ Mg with Al ⁄ Mg, yielding an isochron corresponding to an initial (Al ⁄ Al)o = (5.27 ± 0.18) · 10 and an in...

Leonhard-Marek, Sabine, Friederike Stumpff, Inge Brinkmann, Gerhard Breves, and Holger Martens. Basolateral Mg / Na exchange regulates apical nonselective cation channel in sheep rumen epithelium via cytosolic Mg . Am J Physiol Gastrointest Liver Physiol 288: G630–G645, 2005. First published November 18, 2004; doi:10.1152/ajpgi.00275.2004.—High potassium diets lead to an inverse regulation of s...

Pseudobulbar affect (PBA) is a dysfunction of emotional expression characterized by involuntary outbursts of crying or laughing disproportionate or unrelated to mood, occurring in patients with various underlying neurologic disorders. This review describes the clinical data supporting dextromethorphan (DM) hydrobromide combined with quinidine sulfate (Q) as treatment of PBA and briefly surveys ...

We conducted a retrospective study to assess pharmacoeconomic outcomes of patients who received a daily dose of micafungin 100 mg or 150 mg to treat candidemia. The once-daily 100-mg dose resulted in clinical and mycological outcomes similar to those achieved with 150 mg daily and succeeded in reducing drug-acquisition costs for treating hospitalized patients with candidemia.