The nomenclature of hepatocyte nuclear factor-4 receptors is agreed by the NC-IUPHAR Subcommittee on Nuclear Hormone Receptors [9, 3]. While linoleic acid has been identified as endogenous ligand for HNF4α its function remains ambiguous [75]. HNF4γ yet to be paired with an ligand.

Plant lipid transfer proteins are a large family that can be found in all land plants. They have hydrophobic cavity allows them to harbor lipids and facilitates their traffic between membranes. However, humans, this plant protein is responsible for the main food allergies Mediterranean area. Nevertheless, not only itself but also its ligand relevant allergic sensitization. The aim of present wo...

This paper is intended to prepare new antimicrobial complexes with proven efficiency. The Schiff base, through the condensation process of salicylaldehyde and p-toludine, its Cu Zn were successfully synthesized. base characterized using molar conductivity, Ultraviolet-visible (UV-Vis), atomic absorption spectroscopy (AAS), Fourier transform infrared (FTIR) techniques. Accordingly, these charact...

MthK is a prokaryotic Ca(2+)-gated K(+) channel that, like other ligand-gated channels, converts the chemical energy of ligand binding to the mechanical force of channel opening. The channel's eight ligand-binding domains, the RCK domains, form an octameric gating ring in which Ca(2+) binding induces conformational changes that open the channel. Here we present the crystal structures of the Mth...

Coadsorbed organic species including thiolates can promote direct synthesis of hydrogen peroxide from H2 and O2 over Pd particles. Here, density functional theory based kinetic modeling, augmented with activity measurements vibrational spectroscopy are used to provide atomistic understanding H2O2 formation alkylthiolate(RS) Pd. We find that the RS oxidized during reaction conditions yielding RS...