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The effect of intravenous injection of beryllium nitrate to adult female Albino rats primed with Liv.52 and to non-primed rats has been studied on various hematological parameters after 2, 10 and 30 days of such injection. There was a significant decrease in RBC count, Hb%, neutrophils, blood sugar, alkaline phosphatase, globulin and total protein values with the administration of beryllium nit...

This article is a review of the human pulmonary disorders which may result from exposure to inhaled metals. Since carbon and silicon are not metals, this review does not cover coal workers' pneumoconiosis, silicosis, asbestos-related diseases, or pneumoconioses caused by other silicates. The type of lung disease caused by metal compounds depends on the nature of the offending agent, its physico...

Beryllium binding to human and both inbred and outbred guinea pig lymphocytes has been characterized by Scatchard binding analysis. In isotonic media, only one class of binding sites, presumed to be located on the outer cell surface, was identified with a relatively low affinity (KA 3–4 × 10 M). In hypotonic media in which the cells rupture, an additional class of binding sites, probably in the...

The toxic effects of beryllium salts have been studied on the reproductive organs of cyclic adult female albino rats; simultaneously an attempt has been made to overcome these effects by using an Ayurvedic remedy Liv.52 (The Himalaya Drug Co., Bombay). Liv.52-primed rats (1 ml/rat/d for 15 days) were exposed to beryllium nitrate intravenously and were sacrificed at different time intervals. At ...

Beryllium (Be) presentation to CD4 T cells from patients with chronic beryllium disease (CBD) results in T cell activation, and these Be-specific CD4 T cells undergo clonal proliferation and Th1-type cytokine production. In exposed workers, genetic susceptibility to this granulomatous disorder is associated with particular HLA-DPB1 alleles. We hypothesized that these HLA-DP molecules could medi...