The inability of the systemic antioxidants to alleviate the exacerbation of free radical formation from metabolic outputs and environmental pollutants claims an urgent demand for the identification and design of new chemical entities with potent antioxidant activity. In the present work, different QSAR approaches have been utilized for identifying the essential structural attributes imparting a...

A series of new coumarin-derived carboxylate ligands and their silver(I) complexes have been synthesized, characterized and screened for their in vitro antibacterial activity against a range of Gram-positive and Gram-negative bacteria as well as for their antifungal activity against a clinical isolate of Candida albicans. The ligands were synthesised by either acid or base hydrolysis of their c...

In the title compound, C19H10ClNO4, the dihedral angle between the naphtho-quinone and coumarin rings is 48.99 (6)°. In the crystal, mol-ecules are linked by strong N-H⋯O hydrogen bonds into chains with graph-set motif C(6) along [101]. The packing also features π-π stacking inter-actions between naphtho-quinone and coumarin rings [centroid-to-centroid distances = 3.7679 (12) and 3.6180 (13) Å].

In the title compound C(14)H(14)BrNO(3), the coumarin ring system is almost planar (r.m.s. deviation = 0.008 Å) and an intra-molecular C-H⋯O inter-action generates an S(6) ring. In the crystal, mol-ecules are linked by N-H⋯O hydrogen bonds, with the C=O unit of the coumarin ring system acting as the acceptor group, generating [010] C(8) chains. The chain connectivity is reinforced by two C-H⋯O ...

Synthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk diffusion assay, against thirteen str...

Enzyme activities of the CYP enzymes (CYP3A4, CYP2C9 and CYP2A6) were determined using classical substrates (testosterone, diclofenac and coumarin, respectively) as well as with luminogenic or fluorogenic substrates in micromethod arrangement. The luciferin-based luminogenic substrates for CYP3A4 and CYP2C9 as well as coumarin in micromethod for assay of CYP2A6 activity gave results well compar...

The title compound, C(26)H(24)N(2)O(2), was prepared from the reaction of 4-chloro-3-formyl-coumarin with p-methyl-benzyl-amine. Even though there are no strong and specific inter-actions in the crystal structure, the translationally related mol-ecules form chains along the b axis. The coumarin moieties are stacked through π-π inter-actions [centroid-centroid distance = 3.5275 (7) Å], forming l...

In order to extend the photoactivity of titanium dioxide into visible region, highly porous nitrogen-doped TiO2 catalysts (NTiO2) were successfully synthesized by a modified co-precipitation method with ammonium hydroxide as nitrogen source. Different approaches such dosing reagents and temperature synthesis, calcination period tested examine optimum outcome regarding photocatalytic OH radical ...

1. Abstract Liquid crystal (LC) devices incorporating photosensitive polymers based on coumarin were investigated for laser beam shaping applications. Presently, the OMEGA EP laser system uses pixelated metal beam shaping devices, though their relatively low damage threshold (approximately 0.2 J/cm 2) makes them poor options for long-term usage. LC devices have the major advantages of a much hi...