Osteosarcoma, the most common primary malignant bone tumor, usually arises in the metaphysis of long bones. Amplification and mutation of the epidermal growth factor receptor (EGFR) gene represent signature genetic abnormalities encountered in osteosarcoma. Noscapine is a benzylisoquinoline alkaloid derived from the opium poppy Papaver somniferum. Recently several studies have suggested its ant...

Two new alkaloids were isolated together with 16 known lupin alkaloids from the leaves and stems of Chinese Maackia amurensis. Their structures were determined by spectroscopic methods to be (-)-6alpha-methoxylupanine and (-)-5alpha-(12-cytisinylmethyl)-6alpha-hydroxylupan ine and identified by comparison with synthetic samples. The structures of lupin alkaloids were also related to the geograp...

Chopra and others (1927) have shown that the alkaloids of Holarrliena antidysenterica possess marked amcebicidal properties, and Ghosh and Ghosh (1928) have shown that the Indian species of H. antidysenterica contain, besides conessine, two other alkaloids which they named kurchicine and kurcliine, respectively. Ghosh and Bose (1932) isolated these alkaloids in pure form and showed that the alk...

Leucofoline and leuconoline, representing the first members of the aspidospermatan-aspidospermatan and eburnane-sarpagine subclasses of the bisindole alkaloids, respectively, were isolated from the Malayan Leuconotis griffithii. The structures of these bisindole alkaloids were established using NMR and MS analysis, and in the case of leuconoline, confirmed by X-ray diffraction analysis. Both al...

Three novel β-carboline alkaloids characterized with a unique degraded monoterpenoid moiety, gelebolines A-C (1-3), together with 11 known alkaloids of different types, were isolated from the roots of Gelsemium elegans. The structures of new alkaloids were established on the basis of analysis of spectroscopic data. It is the first example for report of β-carboline from genus Gelsemium (Loganiac...

Cell suspension of Hyoscyamus a/bus L. were investigated for growth and production of tropane alkaloids in three different media. The effects of sucrose concentration and initial pH were also studied. 2,4Dichlorophenoxyacetic acid and 1% sucrose enhanced the production of tropane alkaloids. The percent of alkaloids (0.75%) was higher than in the cultivated plant (0.352 %).

Over four hundred alkaloids in amphibian skin have been detected and structures from twenty different classes have been elucidated. These include batrachotoxins, histrionicotoxins, pumiliotoxins, epibatidine, pyrrolidines, piperidines, decahydroquinolines, pyrrolizidines, indolizidines, quinolizidines and tricyclic gephyrotoxins, pyrrolizidine oximes, pseudophrynamines, coccinellines and cyclop...

Three new pavine N-oxide alkaloids, (-)-isocaryachine-N-oxide B, (+)-caryachine-N-oxide, (-)-caryachine-N-oxide, and a new isoquinoline alkaloid, 6,7-methylenedioxy-N-methylisoquinoline together with 11 known alkaloids were isolated and characterized from the stem bark of Cryptocarya chinensis. The structures of the isolated compounds were determined by spectral methods. The stereochemistry of ...

Background & Aim: A. belladonna (family: Solanaceae) is one of important pharmaceutical plants which contain tropane ‎alkaloids. Tropane alkaloids are distinct group of secondary metabolites of the ‎Solanaceae family.  The most important alkaloids of A. belladonna are atropine and hyoscine that are used extensively because of their medicinal properties. There...

the pyrrolizidine alkaloids (pas) are a group of chemicals found in a variety of plant species throughout the world. these toxic alkaloids are distributed mainly in senecio (compositae), crotalaria (legominosae) and heliotropium (boraginaceae) species. plants containing these alkaloids cause significant mammalian morbidity and mortality, especially in humans. upon ingestion, metabolic activatio...