OBJECTIVE To determine environmental risk factors for bacillary angiomatosis-bacillary peliosis (BAP), and to confirm infection with Rochalimaea species. DESIGN Case-control study. SETTING Community and university hospitals and clinics. PATIENTS Case patients (N = 48) had biopsy-confirmed BAP. Controls (N = 94) were matched to patients by institution and by human immunodeficiency virus (H...

Knowledge of the ability of the female reproductive system to metabolize environmental chemicals is critical not only from the standpoint of toxicity but also from infertility risk assessment. Benzo(a)pyrene (BaP) is a toxicant that is released into the environment from automobile exhausts, cigarette smoke, burning of refuse, industrial emissions, and hazardous waste sites. In exposed animals, ...

Benzo[a]pyrene (BaP) is a human carcinogen that covalently binds to DNA after activation by cytochrome P450 (P450). Here, we investigated whether NADH:cytochrome b5 reductase (CBR) in the presence of cytochrome b5 can act as sole electron donor to human P450 1A1 during BaP oxidation and replace the canonical NADPH:cytochrome P450 reductase (POR) system. We also studied the efficiencies of the c...

Optimization of in vitro regeneration protocol using multiple input variables is highly significant, and can be achieved by validating the data machine learning algorithms. Shoot tip nodal segment explants Alternanthera reineckii mini were inoculated on Murashige Skoog (MS) medium enriched with different concentrations benzylaminopurine (BAP), cultured under five monochromic light-emitting diod...

An efficient in vitro direct shoot regeneration system has been described for Lycium chinense Miller using leaf explants. Influence of various parameters such as growth regulator concentration, explant type, effect basal salt Murashige and Skoog (1962) medium (MS), Schenk Hildebrandt (1972) (SH), Gamborg et al. (1968) (B5), carbon sources (sucrose, maltose, fructose) on the regenerating shoots ...

The instability of in vitro cultures may cause genetic and epigenetic changes crops called somaclonal variations. Sometimes, these produce beneficial effects; for example, they can be used breeding programs to generate new cultivars with desirable characteristics. In this article, we present a systematic review designed answer the following question: How does variation contribute plant improvem...

The great economic importance of sugar beet determines the ongoing biotechnological studies conducted worldwide to improve technology obtaining doubled haploids (DHs) using method unpollinated ovule culture in vitro. To induction gynogenesis, we tested effect thidiazuron (TDZ), temperature bud pretreatment, different concentrations sucrose, and culturing on liquid or solid medium. Three genotyp...

Context—There now exist multiple reports of a constellation of language, personality, and socialbehavioral features present among relatives that mirror the symptom domains of autism, but much milder in expression. Studies of this ‘broad autism phenotype’ (BAP) may provide a potentially important, complementary approach for detecting the genes causing autism and defining associated neural circui...

Pulmonary inflammation can contribute to the development of lung cancer in humans. We investigated whether pulmonary inflammation alters the genotoxicity of polycyclic aromatic hydrocarbons (PAHs) in the lungs of mice and what mechanisms are involved. To model nonallergic acute inflammation, mice were exposed intranasally to lipopolysaccharide (LPS; 20 µg/mouse) and then instilled intratracheal...