The use of 4-amino-5-benzyl-4H-[1,2,4]triazole-3-thiol (1) as a precursor to synthesize some new biologically active heterocycles has been found to be effective. Condensation of 1 with appropriate aldehydes gave the new Schiff bases 2a, b, which either by cyclization with thioglycolic acid gave 3a, b, or by Mannich reaction using morpholine gave 4a, b. Reaction of 1 with different halogen compo...

rac-Benzyl 3-oxohexa-hydro-1H-pyrrolo[3,4-c]pyridine-5(6H)-carboxyl-ate was separated by chiral chromatography, and one of the enanti-omers ([α](22) (D) = +10°) was hydrogenated in the presence of Pd/C in methanol, producing octa-hydro-3H-pyrrolo[3,4-c]pyridin-3-one. The latter was reacted with (2R)-3,3,3-trifluoro-2-meth-oxy-2-phenyl-propanoyl chloride [(R)-(-)-Mosher acid chloride], giving ri...

In the present work, vinyl benzyl chloride (VBC) was polymerized by using free radical polymerization. The obtained PVBC reacted with dibutyl amine to obtain tertiary modified polystyrene based polymer (PVBC-Dibutyl amine). inverse gas chromatography (IGC) method used examine thermodynamic properties of polymer. Firstly, retention diagrams some polar and non-polar solvents on PVBC-Dibutyl were ...

In this research, 15 novel derivatives of the thiazolactone skeleton were synthesized using Erlenmeyer–Plöchl reaction procedure. Glycine, alanine and leucine amino acids used to make dithiocarbamate precursor by reacting with carbon disulfide benzyl chloride. Obtained underwent formation in presence acetic anhydride then condensed arylglyoxals as condensing carbonyl group source. Products char...

Ferrocene containing N-heterocyclic carbene (NHC) ligated gold(I) complexes of the type [Au(NHC)2]+ were prepared and found to be capable of regulating the formation of reactive oxygen species (ROS) via multiple mechanisms. Single crystal X-ray analysis of bis(1-(ferrocenylmethyl)-3-mesitylimidazol-2-ylidene)-gold(I) chloride (5) and bis(1,3-di(ferrocenylmethyl)imidazol-2-ylidene)-gold(I) chlor...