γ-Glutamylcyclotransferase (GGCT) is involved in glutathione homeostasis, which it catalyzes the reaction that generates 5-oxoproline and free amino acids from γ-glutamyl peptides. Increasing evidence shows GGCT has oncogenic functions overexpressed various cancer tissues, inhibition of activity exerts anticancer effects vitro vivo. Here, we demonstrate U83836E ((2R)-2-[[4-(2,6-dipyrrolidin-1-y...

The asymmetric unit of the title compound, {[Na(C(9)H(6)O(3))(H(2)O)(3)](C(9)H(5)O(3))·H(2)O}(n), contains two crystallographically independent Na atoms, two 7-hy-droxy-coumarin ligands, six coordinated water mol-ecules, two 7-hy-droxy-coumarin anions and two uncoordinated water mol-ecules. Both Na atoms exhibit a distorted octa-hedral coordination geometry and are coordinated by five water O a...

Six new flavonoids 2',4'-dihydroxychalcone-6'-O-β-d-glucopyranoside (1), α,3,2',4'-tetrahydroxy-4-methoxy-dihydrochalcone-3'-C-β-glucopyranosy-6'-O-β-d-glucopyranoside (2), 7-hydroxy-5,8'-dimethoxy-6'α-l-rhamnopyranosyl-8-(3-phenyl-trans-acryloyl)-1-benzopyran-2-one (3), 6'7-dihydroxy-5,8-dimethoxy-8(3-phenyl-trans-acryloyl)-1-benzopyran-2-one (4), 9-hydroxy-3,8-dimethoxy-4-prenylpterocarpan (5...

A critical factor in the cause and progression of Alzheimer’s disease (AD) is growth ?-amyloid peptide (A?) brain. The mechanism this effect still unknown, although osthol on A?-induced inflammation neuroprotective AD supplementation with zinc might prevent or delay onset dementia. In current study, by inducing APP vector human BE (2)-M17 cells, we established a cellular model investigated prot...

A series of 6H,7H-7-(4-Hydroxy-3-coumarinyl)[1]benzopyrano[4,3-b][1]benzopyran-6-ones 4a-g and 3-(2-hydroxybenzoyl)-2H-chromen-2-ones 5a-g derivatives were synthesized by reaction 4-hydroxycoumarin with 2-hydroxyarylaldehydes 2a-f or 2-hydroxynaphtaldehyde 2g using different solvents acid/base catalysts. The approach relies on a regioselective cascade involving one/two molar equiv the 4-hydroxy...

The purpose of this study was to analyze the optimal dose Tembelekan leaf extract (Lantana camara Linn) which has antibacterial properties in inhibiting or killing Edwardsiella tarda bacteria. method used research is Completely Randomized Design (CRD). results yield obtained from tembelakan amounted 8.9%. positive phytochemical test contained active compounds, namely flavonoids, alkaloids, tann...