Ionotropic gamma-aminobutyric acid (GABA(A)) receptors control the relay of nociceptive signals at several levels of the neuraxis. Experiments with systemically applied benzodiazepines, which enhance the action of GABA at these receptors, have suggested both anti- and pronociceptive effects. The interpretation of such experiments has been notoriously difficult because of confounding sedation. H...

Anumber of compounds, including triazolam (1,2), pentobarbital (3), ethanol (4), and adenosine (5) have been shown to induce sleep when injected into the medial preoptic area of rats. The mechanism by which this occurs remains to be clearly elucidated, though the high affinity for triazolam for the benzodiazepine recognition site on the GABA-A-benzodiazepine receptor complex, and the interactio...

AIMS Hypnotic zolpidem is a positive allosteric modulator of γ-aminobutyric acid (GABA) action, with preferential although not exclusive binding for α1 subunit-containing GABA(A) receptors. The pharmacological profile of this drug is different from that of classical benzodiazepines, although it acts through benzodiazepine binding sites at GABA(A) receptors. The aim of this study was to further ...

PURPOSE To determine the changes in the adenosine A(1) and benzodiazepine receptor density and in glucose metabolism in the visual centers of the rat brain following monocular enucleation or eyelid suture on postnatal day 10 (PN10). METHODS Following monocular enucleation or eyelid suture on PN10 rats, the alterations in adenosine A(1) and benzodiazepine receptor density, and in glucose metab...

Our goal was to attempt to establish neuropharmacological tinnitus control (i.e., relief) with medication directed to restoration of a deficiency in the gamma-aminobutyric acid-benzodiazepine-chloride receptor in tinnitus patients with a diagnosis of a predominantly central type tinnitus. Thirty tinnitus patients completed a medical audiological tinnitus patient protocol and brain magnetic reso...

We report the identification and characterization of 2 classes of benzodiazepine binding sites in the embryonic chick CNS. Binding was examined by competition and saturation binding experiments, using as radioligands 3H-flunitrazepam, a classical benzodiazepine anxiolytic, and 3H-Ro5-4864, a convulsant benzodiazepine. The results demonstrate that high-affinity (KD = 2.3 nM) 3H-flunitrazepam bin...

The anterior cingulate cortex (ACC; BA 24) via its extensive limbic and high order association cortical connectivity to prefrontal cortex is a key part of an important circuitry participating in executive function, affect, and socio-emotional behavior. Multiple lines of evidence, including genetic and imaging studies, suggest that the ACC and gamma-amino-butyric acid (GABA) system may be affect...

BACKGROUND AND PURPOSE Misery perfusion may cause selective neuronal damage in atherosclerotic ICA or MCA disease. Bypass surgery can improve misery perfusion and may prevent neuronal damage. On the other hand, surgery conveys a risk for neuronal damage. The purpose of this retrospective study was to determine whether progression of cortical neuronal damage in surgically treated patients with m...

conclusions zolpidem dependency and withdrawal seizure can occur with a dosage under last reported doses. therefore, possibility of mentioned problems cannot be excluded at any dosage and physicians should pay more attention to potential of zolpidem to create these adverse effects. introduction zolpidem is a short acting inducer of sleep and thought to lack benzodiazepine properties such as anx...

856 benzodiazepine photoaffinity labelling site on the GABA, receptor a 1 subunit [ 121. Further, it should be pointed out that an alternative approach to synthetic peptides as antigens for directed antibody production is the use of bacterially produced subunit fragments, and indeed this strategy has been adopted for the GAHA, receptor [13]. In general these antigens, although probably less exp...