BACKGROUND Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung’s disease. Studies using animal models on the pathogenesis HAEC are limited. Thus, this study aimed to establish rat model topical application 0.1% benzalkonium chloride (BAC) in sigmoid colon.
 METHODS 55 male Sprague Dawley rats aged 10−12 weeks old were separated into 11 groups. Th...

The report of Stevenson and Bolduan (Science, 116, 111, 1952) that species of bacteria could be differentiated by their infrared spectra suggested that this technique might be employed to study the effects of antibacterial agents on the organism. The preliminary experiments here reported were concerned with the effect of benzalkonium chloride (0.1 per cent) and phenol (5 per cent) upon the infr...

Benzalkonium chloride (BAC) is a mixture of alkyl substituted benzyl dimethylammonium chloride homologs (C12-BAC, C14-BAC and C16-BAC). Chlorhexidine acetate is a widely used effective component in compound chemical disinfectants. A method for the simultaneous determination of chlorhexidine acetate and benzalkonium chloride in compound chemical disinfectants by capillary electrophoresis (CE) wa...

BACKGROUND There is much to learn about the effectiveness of different methods currently used for the irrigation of open wounds. The purpose of this study was to compare various approaches in a survival animal model. METHODS We used an established goat model involving the creation of a reproducible complex musculoskeletal wound followed by inoculation with Pseudomonas aeruginosa (lux) bacteri...

Sarcopoterium spinosum (L.) is a medicinal plant traditionally used for the treatment of various diseases including cancer in Near- and Middle East. The fractions constituents ethanol extract S. were screened vitro cytotoxic activities on Jurkat (acute T-lymphoblastic leukemia), HeLa (cervical adenocarcinoma), MCF-7 (mammary gland Caco-2 (human colorectal MDA-MB-231 adenocarcinoma) cell lines u...

Benzalkonium chloride (BAK) is a mixture of alkyl benzyl dimethyl ammonium chlorides, which used primarily as biocide, surfactant, preservative, and antimicrobial agent in the pharmaceutical industry, particular ophthalmologic nasal solutions. However, BAK may cause harmful consequences on eye structures anterior segment. Control identity content necessary by applying sensitive detection method...