نتایج جستجو برای: basophil activation test
تعداد نتایج: 1222054 فیلتر نتایج به سال:
Clinical & Experimental AllergyVolume 51, Issue 7 p. 980-981 CORRESPONDENCE Basophil activation test in the diagnosis of hypersensitivity reactions to quinolones by Loli-Ausejo et al Didier G. Ebo, Corresponding Author [email protected] orcid.org/0000-0003-0672-7529 Faculty Medicine and Health Sciences, Department Immunology, Allergology, Rheumatology Infla-Med Centre Excellence, University ...
Background Rapid Drug Desensitization (RDD) has become a cornerstone of the management of immediate hypersensitivity reactions (HSRs) to chemotherapeutic agents, including biologicals. It is the only effective procedure for overcoming HSRs to first-line therapy, thus representing an important advance in patients’ treatment and prognosis. Biomarkers to assess drug sensitization and monitor RDD s...
INTRODUCTION This multicenter study aimed to evaluate the diagnostic value of 2 cellular tests based on basophil reactivity--the basophil activation test (BAT, Flow-CAST) and the sulfidoleukotriene release assay (CAST-ELISA)--in immediate-type beta-lactam allergy, particularly in patients with a clinical history of allergy and a negative skin test result. MATERIAL AND METHODS In a multicenter...
OBJECTIVE At present, no reliable in vitro test is available to monitor the success of specific venom immunotherapy (VIT) in preventing insect venom anaphylaxis. We investigated usefulness of the basophil activation test (BAT) in predicting the outcome of sting challenge in bee venom-allergic patients after VIT. PATIENTS AND METHODS Twenty-one patients with bee venom anaphylaxis at the end of...
Background Desensitization (DST) has become a cornerstone in the management of immediate hypersensitivity reactions (HSRs) to chemotherapic agents. It is the only effective procedure for overcoming HSRs to first-line therapy, thus representing an important advance in patients’ treatment and prognosis. Nevertheless, there are still no good biomarkers to monitor DST safety and effectiveness. The ...
Background When exclusive breastfeeding is not possible, partially hydrolyzed formula (PHF) often used as a starter for infants. Some children develop allergic symptoms, including anaphylaxis, after the first intake of cow protein. Therefore, tolerability PHF in infants with cow's milk allergy (CMA) important information. Partially whey (PHWF) well characterized, but those containing both and c...
IgE-mediated mast cell activation is the trigger of anaphylaxis in humans, whereas it is known that not only IgE but also IgG can induce anaphylaxis in mice. In our preliminary experiments, the expression of a murine basophil identification marker, CD200R3, on antigen-sensitized basophils decreased following specific antigen challenge. Interestingly, this decrease did not always correspond with...
Rationale In Southern Europe Pru p3 is the primary sensitizer of plants fruit and it is responsible of severe reactions. Specific immunotherapy (SIT) brings a new perspective to treat those patients. There is a lack of knowledge regarding cellular responses that include changes in the basophil activation during the IT. We aim to analyse early changes in the basophil response to Pru p 3 and othe...
BACKGROUND It has previously been demonstrated that subcutaneous immunotherapy with allergoids positively affects clinical and immunological parameters even after 7 preseasonal injections. However, its effect on basophil activation remains unclear. We investigated the effect of preseasonal allergoid immunotherapy on basophils and concomitantly assessed its clinical and immunological efficacy in...
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