Structural and functional integrity of organ function profoundly depends on a regular oxygen and glucose supply. Any disturbance of this supply becomes life threatening and may result in severe loss of organ function. Particular reductions in oxygen availability (hypoxia) caused by respiratory or blood circulation irregularities cannot be tolerated for longer periods due to an insufficient ener...

Steel converter slag, also called Linz-Donawitz (LD) has been considered as an oxygen carrier for biofuel chemical looping applications due to its high availability. In addition content of iron which contributes oxygen-carrying capacity, LD slag contains a significant amount calcium. Calcium, however, is known interact with sulfur, may affect the usability slag. To get better understanding inte...

Structural properties of amorphous In-based oxides, In-X-O with X = Zn, Ga, Sn, or Ge, are investigated using ab initio molecular dynamics liquid-quench simulations. The results reveal that indium retains its average coordination of 5.0 upon 20%X fractional substitution for In, whereasX cations satisfy their natural coordination with oxygen atoms. This finding suggests that the carrier generati...

The effects of resuscitation fluids on the brain have been investigated in previous studies by global measurements of cerebral blood flow and metabolism. In this study we have examined the effects of a novel haemoglobin-based oxygen carrier on local cerebral blood flow (LCBF) and local cerebral glucose utilization (LCGU) after resuscitation from a volume-controlled haemorrhage of 30 min (3.0 ml...

Certain strains of Streptococcus faecalis when grown under highly aerobic conditions acquire a mechanism that permits them to oxidize a number of substrates without accumulating H202, and in addition enables them to rid the medium of added H202 during the metabolism of these substrates (Seeley and VanDemark, 1951). This mechanism does not involve catalase or the common hematin-containing peroxi...

BACKGROUND Preclinical imaging requires anaesthesia to reduce motion-related artefacts. For direct translational relevance, anaesthesia must not significantly alter experimental outcome. This study reports on the effects of both anaesthetic and carrier gas upon the uptake of [⁶⁴Cu]-CuATSM, [(⁹⁹m)Tc]-HL91 and [¹⁸F]-FMISO in a preclinical model of tumor hypoxia. METHODOLOGY/PRINCIPAL FINDINGS T...

Oxygen is the lifeline of variety of organisms present on the earth. It is one of the basic elements that are involved in the formation of the functional unit of a living being. Various intricacies and mechanisms are there inside the organism that transports the oxygen to each and every cell of the body. Failure of oxygen to reach the brain leads to various kinds of neurodegenerative disease. H...