Normal and nephrectomized SpragueDawley rats were treated with CoCI2 at three dose levels, 10, 20, and 25 tm/ 100 g body weight. The effects of this drug on acid-base balance were related to the production of erythropoietin. Within 6 hr after the administration of CoCI2 to normal rats, a dose-related respiratory alkalosis occurred associated with an increase in the affinity of hemoglobin for ox...

The regulation of the acid-base balance in cells is essential for proper cellular homeostasis. Disturbed acid-base balance directly affects cellular physiology, which often results in various pathological conditions. In every living organism, the protein family of carbonic anhydrases regulate a broad variety of homeostatic processes. Here we describe the identification, mapping and cloning of a...

In humans, acid-base balance is crucial to cell homeostasis. Acidosis is observed in numerous inflammatory processes, primarily acute conditions such as sepsis, trauma, or acute respiratory distress where females tend to exhibit better prognosis compared with males. The mechanisms underlying these gender-dependent differences are multiple, probably involving hormonal and genetic factors, partic...

Disorders of acid-base balance are among the most common abnormalities seen, especially in critically ill and injured patients. While many disorders are benign or self-limiting, severe disorders of acid-base balance are life threatening, especially when these derangements develop quickly. Although controversy exists as to the effect of mild to moderate acid-base disorders, severe abnormalities ...