AIMS AND METHODS Acute alcohol administration induces marked decreases in glucose metabolism throughout the human brain. However, the relationship between alcohol's effects on brain metabolism and the behavioural changes that occur with intoxication are still unclear. Here we assessed this association using principal component analysis for dimension reduction and canonical correlations to gauge...

K-Ras dependent non-small cell lung cancer (NSCLC) cells are 'addicted' to basal autophagy that reprograms cellular metabolism in a lysosomal-sensitive manner. Here we demonstrate that the xenophagy-associated kinase TBK1 drives basal autophagy, consistent with its known requirement in K-Ras-dependent NSCLC proliferation. Furthermore, basal autophagy in this context is characterised by sequestr...

At physiological maturity (PM), the maize grain shows a metabolic and gene transcriptional basal rate which is mainly related to primary metabolism cellular respiration, among other pathways. It well known that adult plants are capable of responding volatile organic compounds, but little evidence this has been observed in seeds. The investigation induction seeds oxylipin metabolism, defense sys...

Basal metabolic rates in mammals are mainly determined by body mass, but also by ecological factors. Some mammalian species inhabiting hot, dry environments were found to have lower metabolic rates compared to temperate species. We studied energy metabolism in Phillip's dikdik (Madoqua saltiana phillipsi), a small antelope inhabiting xeric shrubland habitats in the Eastern 'horn' of Africa, and...

A comparative analysis of genome-scale transcriptomic data of two types of skin cancers, melanoma and basal cell carcinoma in comparison with other cancer types, was conducted with the aim of identifying key regulatory factors that either cause or contribute to the aggressiveness of melanoma, while basal cell carcinoma generally remains a mild disease. Multiple cancer-related pathways such as c...