background: the most frequently mutated tumor suppressor gene found in human cancer is p53. in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or to induce apoptosis. however, when mutated, p53 is no longer able to properly accomplish these functions. the aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

Basal cell carcinoma (BCC) is the most common malignant tumor of the skin, which originates from the basal cell layer of the skin. It is more common in white race with skin types I and II. Some predisposing factors are sunlight, ionizing radiation, arsenic salts, PUVA and scar. We present a case of BCC, which appeared over an old scar of localized cutaneous leishmaniasis in a 49-year-old woman.

Abstract Introduction Racemic ketoconazole (RK) is a steroidogenesis inhibitor used for treatment of Cushing’s syndrome. Levoketoconazole (COR-003), the pure 2S,4R enantiomer, potentially more potent and safe compared to RK. We in vitro effects levoketoconazole RK on adrenocortical pituitary adenoma cells. Materials methods HAC15 cells 15 primary human neoplastic cultures (+/− ACTH), murine (At...

normal 0 false false false en-us x-none ar-sa leishmaniasis is a protozoan infection due to organisms of the genus leishmania. the differential diagnosis of cutaneous leishmaniasis includes arthropod bites, basal cell carcinoma (bcc) and other malignancies. bcc is the most common form of skin cancer. we present a case of cutaneous leishmaniasis resistant to standard intralesional glucantime inj...

Mouse models can be useful for increasing the understanding of lung tumorigenesis and assessing the potential of chemopreventive agents. We explored the role of inflammation in lung tumor development in mice with knockout of the tumor suppressor Gprc5a. Examination of normal lung tissue and tumors from 51 Gprc5a(+/+) (adenoma incidence, 9.8%; adenocarcinoma, 0%) and 38 Gprc5a(-/-) mice (adenoma...

Initial investigations reported GATA3 to be a sensitive and relatively specific marker for mammary and urothelial carcinomas. Recently, GATA3 expression has been described in several other epithelial tumors. However, there has been only limited investigation of GATA3 expression in cutaneous epithelial tumors. The objective of this study was to examine the immunohistochemical expression of GATA3...

OBJECTIVE To evaluate the diagnostic accuracy of inferior petrosal sinus sampling (IPSS) in the differential diagnosis of ACTH-dependent Cushing's syndrome as compared with pituitary imaging techniques. DESIGN AND METHODS We retrospectively studied the diagnostic accuracy of basal and post corticotropin-releasing hormone (CRH) IPSS, magnetic resonance imaging and computed tomography in distin...

background and objective: clinical behavior of basal cell carcinoma (bcc) is known to be different according to histological growth pattern and basosquamous cell carcinomas (bsc) are known with their aggressive behavior and metastatic capacity. in this study, we evaluated bcl-2 and cyclin d1 expressions in bcc and bsc cases comparatively, to explore their predictive value on the aggressive beha...

malignancies of the midface result in cosmetic deformities that make maxillofacial prosthesis as an integral part of the treatment plan. facial defects can be devastating in their impact on physical structure and function of the affected individual, leading to potentional compromises in quality of life. reconstruction of nasal defects is a challenge for the prosthodontist because of esthetic an...