نتایج جستجو برای: barrel bomb

تعداد نتایج: 10295  

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2005
Gordon M G Shepherd Karel Svoboda

Excitatory synaptic projections to layer 2/3 (L2/3) pyramidal neurons in brain slices from the rat barrel cortex were measured using quantitative laser-scanning photostimulation (LSPS) mapping. In the barrel cortex, cytoarchitectonic "barrels" and "septa" in L4 define a stereotypical array of landmarks, allowing alignment and averaging of LSPS maps from multiple cells in different slices. We di...

Journal: :Neuroscience research 2004
Marco Aurélio M Freire Walace Gomes-Leal Walther A Carvalho Joanilson S Guimarães João G Franca Cristovam W Picanço-Diniz Antonio Pereira

The distribution of NADPH diaphorase (NADPH-d)/nitric oxide synthase (NOS) neurons was evaluated during the postnatal development of the primary somatosensory cortex (SI) of the rat. Both cell counts and area measurements of barrel fields were carried out throughout cortical maturation. In addition, NADPH-d and cytochrome oxidase (CO) activities were also compared in both coronal and tangential...

Journal: :Mutation research. Genetic toxicology and environmental mutagenesis 2016
Junko Kajimura Seishi Kyoizumi Yoshiko Kubo Munechika Misumi Kengo Yoshida Tomonori Hayashi Kazue Imai Waka Ohishi Kei Nakachi Nan-Ping Weng Lauren F Young Jae-Hung Shieh Malcolm A Moore Marcel R M van den Brink Yoichiro Kusunoki

Accumulated DNA damage in hematopoietic stem cells is a primary mechanism of aging-associated dysfunction in human hematopoiesis. About 70 years ago, atomic-bomb (A-bomb) radiation induced DNA damage and functional decreases in the hematopoietic system of A-bomb survivors in a radiation dose-dependent manner. The peripheral blood cell populations then recovered to a normal range, but accompanyi...

Journal: :Journal of physics 2023

Abstract This paper is devoted to research the interface failure mechanism of coating in gun barrel, three models (interface shear failure, bending and crack growth failure) barrel are built with consideration thermal-pressure coupling effect, criterion given. The critical length/thickness ratio segments for different during firing process calculated based on temperature field simulation result...

Journal: :British Dental Journal 2020

2012
Rajeev Misra

In the last decade, there has been an explosion of publications on the assembly of β-barrel outer membrane proteins (OMPs), which carry out diverse cellular functions, including solute transport, protein secretion, and assembly of protein and lipid components of the outer membrane. Of the three outer membrane model systems-Gram-negative bacteria, mitochondria and chloroplasts-research on bacter...

Journal: :Journal of neurophysiology 2002
Nora Laaris Asaf Keller

Our aim was to investigate the patterns of functional inputs and outputs from individual barrels in the mouse somatosensory cortex, and to test the hypothesis that individual barrels in layer IV are functionally independent of direct inputs from neighboring barrels. In a mouse in vitro slice preparation of the barrel cortex, we recorded voltage-sensitive dye signals evoked in response to micros...

Journal: :Journal of neurophysiology 2011
Noah C Roy Thomas Bessaih Diego Contreras

Cortical neurons are organized in columns, distinguishable by their physiological properties and input-output organization. Columns are thought to be the fundamental information-processing modules of the cortex. The barrel cortex of rats and mice is an attractive model system for the study of cortical columns, because each column is defined by a layer 4 (L4) structure called a barrel, which can...

Journal: :Structure 2012
Ulrich Zachariae Robert Schneider Rodolfo Briones Zrinka Gattin Jean-Philippe Demers Karin Giller Elke Maier Markus Zweckstetter Christian Griesinger Stefan Becker Roland Benz Bert L de Groot Adam Lange

The voltage-dependent anion channel (VDAC) is the major protein in the outer mitochondrial membrane, where it mediates transport of ATP and ADP. Changes in its permeability, induced by voltage or apoptosis-related proteins, have been implicated in apoptotic pathways. The three-dimensional structure of VDAC has recently been determined as a 19-stranded β-barrel with an in-lying N-terminal helix....

Journal: :Cell 2013
Jian Qiu Lena-Sophie Wenz Ralf M. Zerbes Silke Oeljeklaus Maria Bohnert David A. Stroud Christophe Wirth Lars Ellenrieder Nicolas Thornton Stephan Kutik Sebastian Wiese Agnes Schulze-Specking Nicole Zufall Agnieszka Chacinska Bernard Guiard Carola Hunte Bettina Warscheid Martin van der Laan Nikolaus Pfanner Nils Wiedemann Thomas Becker

The mitochondrial outer membrane harbors two protein translocases that are essential for cell viability: the translocase of the outer mitochondrial membrane (TOM) and the sorting and assembly machinery (SAM). The precursors of β-barrel proteins use both translocases-TOM for import to the intermembrane space and SAM for export into the outer membrane. It is unknown if the translocases cooperate ...

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