نتایج جستجو برای: barr virus ebv

تعداد نتایج: 400744  

Journal: :Archives of Iranian medicine 2014
Ebrahim Faghihloo Mohammad Reza Saremi Mostafa Mahabadi Hassan Akbari Esmail Saberfar

BACKGROUND/AIMS Gastric cancer (GC) is the second leading cause of cancer-related deaths worldwide and is the most frequent cancer in Iran. Epstein-Barr virus (EBV) has been shown to be associated with gastric cancer. The present study was carried out to investigate the prevalence of Epstein-Barr virus (EBV) associated gastric cancer among Iranian patients. METHODS Ninety formalin fixed paraf...

Journal: :Cancer research 1981
P A Pizzo I T Magrath G Jay

Epstein-Barr viral (EBV) DNA is nearly always detectable in African Burkitt's lymphoma (BL) but is infrequently found in the histologically indistinguishable American BL. We have derived a tumor cell line from a patient with American BL which produces EBV, and we have compared this virus isolate [JLP(c)] with African BL EBV. The American JLP(c) virus immortalizes human umbilical cord lymphocyte...

Journal: :Clinical microbiology reviews 2011
Oludare A Odumade Kristin A Hogquist Henry H Balfour

Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymp...

2014
Martina Vockerodt Fathima Zumla Cader Claire Shannon-Lowe Paul Murray

Although Epstein-Barr virus (EBV) is present in the malignant Hodgkin/Reed-Sternberg (HRS) cells of a proportion of cases of classical Hodgkin lymphoma (cHL), how the virus contributes to the pathogenesis of this disease remains poorly defined. It is clear from the studies of other EBV-associated cancers that the virus is usually not sufficient for tumor development and that other oncogenic co-...

Journal: :Cell & Bioscience 2021

Abstract Background Sterile alpha motif and HD domain 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that restricts the infection of variety RNA DNA viruses, including herpesviruses. The anti-viral function SAMHD1 associated with its dNTPase activity, which regulated by several post-translational modifications, phosphorylation, acetylation ubiquitination. Our recent studies also ...

Journal: :Antimicrobial agents and chemotherapy 2004
Edward Gershburg Ke Hong Joseph S Pagano

The human cytomegalovirus (HCMV) homolog of the Epstein-Barr virus (EBV) protein kinase (PK), UL97, is inhibited by maribavir (1263W94) and selected indolocarbazoles. Here we show that only one of these indolocarbazoles (K252a), but not maribavir, inhibits autophosphorylation of the EBV PK, BGLF4. However, maribavir and another indolocarbazole, NGIC-I, do inhibit EBV DNA synthesis, suggesting t...

Journal: :Journal of virology 2003
Dennis M Walling Abigail L Brown Wiguins Etienne Wendy A Keitel Paul D Ling

We employed a newly developed genotyping technique with direct representational detection of LMP-1 gene sequences to study the molecular epidemiology of Epstein-Barr virus (EBV) infection in healthy individuals. Infections with up to five different EBV genotypes were found in two of nine individuals studied. These results support the hypothesis that multiple EBV infections of healthy individual...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1973
M Nonoyama C H Huang J S Pagano G Klein S Singh

The association of Epstein-Barr virus (EBV) DNA with African tumors was examined by the method of hybridization with complementary RNA. 22 out of 23 biopsies of Burkitt's lymphoma and 18 out of 23 biopsies of nasopharyngeal carcinoma were found to contain EBV DNA. The number of EBV genome equivalents per cell ranged from four to 113. Five out of 24 other African tumors, two adenocarcinomas, and...

Journal: :Biomedical Journal of Scientific and Technical Research 2023

Systemic EBV+ T cell lymphoma of childhood manifests as a rapidly progressive, life-threatening disorder with fulminant clinical course. Of obscure aetiology, systemic may arise in concurrence primary Epstein Barr viral infection wherein infiltrating lymphocytes demonstrate monoclonal rearrangements within receptor (TCR) genes. delineates virus infected cytotoxic CD8+ or activated CD4+ cells an...

2014
Münz Christian

Epstein Barr virus (EBV) causes persistent infection in more than 90% of the human adult population and is associated with 2% of all tumors in humans. This γ-herpes virus infects primarily human B and epithelial cells, but it has been reported to be sensed by dendritic cells (DCs) during primary infection. These activated DCs are thought to contribute to innate restriction of EBV infection and ...

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