BACKGROUND Platelet-rich plasma (PRP) as a storage vehicle of growth factors has been successfully used in clinical applications, but in most cases the platelets were autologous. However, the large volume of blood withdrawn has detrimental effects on patients with anemia or poor general health. To overcome these limitations, this study was designed to separate the growth factors in homologous p...

BACKGROUND The optimal platelet-rich plasma (PRP) for treatment of supraspinatus tendinopathy has not been determined. PURPOSE To evaluate the effect of low- versus high-leukocyte concentrated PRP products on catabolic and anabolic mediators of matrix metabolism in diseased rotator cuff tendons. STUDY DESIGN Controlled laboratory study. METHODS Diseased supraspinatus tendons were treated ...

Red blood cell (RBC) effects on platelet adhesion to a nonbiologic test surface (tetrafluoroethylene propylene copolymer) and platelet aggregation during laminar shear flow for shear rates to 5,680 s-1 (corresponding to shear stress to 200 dyne/cm2) were investigated. Results on hemoglobin (Hb) and adenosine diphosphate (ADP) release from RBCs, percent decrease of single platelets in the bulk, ...

The aim of this study was to evaluate the percentage of reticulated platelets in healthy dogs with breed-related thrombocytopenia. Seventy two dogs, clinically healthy, were enrolled in the study. Blood was collected from the patients and anticoagulated with tripotassium ethylenediaminetetraacetic acid (K3-EDTA) and sodium citrate. Platelet count was obtained by an impedance haematology analyse...

Objective:To investigate the effect of platelet-rich plasma (PRP) injection to lower one-third anterior vaginal wall on sexual function, orgasm, in women with dysfunction by scoring FSFI. Materials and Methods:Three sessions PRP (platelet rich human autologous plasma) were administered fiftyfemale patients dysfunctiondiagnosed FSFI card obtained JAM clinic Benha city Egypt orgasmic disorder. Fe...

Background. Autologous platelet-rich gel (APG) is an effective method to improve ulcer healing. However, the mechanisms are not clear. This study aimed to investigate the antibacterial effect of APG in vitro. Methods. Platelet-rich plasma (PRP), platelet-poor plasma (PPP) and APG were prepared from whole blood of sixteen diabetic patients with dermal ulcers. Antibacterial effects against Staphy...

Autologous platelet-rich plasma (PRP) consists of cytokines, growth factors, chemokines, and a fibrin scaffold derived from the patient’s blood. The mechanism of action for PRP gel is considered to be the molecular and cellular induction of normal wound healing responses similar to that seen with platelet activation.[1,2] There are multiple indications of PRP therapy, but there are few controll...

BACKGROUND & OBJECTIVES Contaminating white blood cells (WBCs) in stored platelet concentrates (PC) are the main source of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin- 8 (IL-8) and tumour necrosis factor-alpha (TNF-alpha) that are implicated in transfusion reactions. We compared the levels of these cytokines in stored platelet preparations prepared by two methods. Eff...

conclusions our study demonstrates positive results (preservation or regeneration of bone) using prp in treatment of bronj. although prp may enhance osseous regeneration, long-term follow-ups are required to confirm its benefits. background bisphosphonate-related osteonecrosis of the jaws (bronj) is a well-known challenging entity warranting management. platelet-rich plasma (prp) plays an impor...

Background: Lateral epicondylitis is a painful condition of the elbow, characterised by pain and tenderness with resisted wrist extension. This study was carried out to evaluate comparative efficacy local infiltration leucocyte enriched platelet rich plasma (L-PRP) methylprednisolone in patients lateral epicondylitis.Methods: Sixty adult patients, between ages 30 50 years, diagnosed more than 1...