Background During exercise, the demand for oxygen and energy substrates is elevated in active skeletal muscle. Supplements with high nitrate and polyphenol content have been shown to increase nitric oxide production and enhance exercise efficiency. The current randomized, double-blind, placebo-controlled, crossover study aimed to investigate the acute effects of pomegranate extract on blood flo...

Colon cancer is one of the major causes of cancer-related death in the Western world. Although cytotoxic chemotherapeutic agents are available to treat the disease, these agents become ineffective as the disease advances to an invasive state. An alternative but viable approach to reduce the incidence of this deadly disease is then, to increase the dietary intake of relatively non-toxic fruits a...

BACKGROUND Co-products obtained from pomegranate juice processing contain high levels of polyphenols with potential high added values. From value-addition viewpoint, the aim of this study was to evaluate the stability of polyphenolic concentrations in pomegranate fruit co-products in different solvent extracts and assess the effect on the total antioxidant capacity using the FRAP, DPPH˙ and ABT...

Background Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications. Methods Diabetes was induced via administration of alloxan (150 mg/kg, intraperitone...

Background: Phenol is an organic pollutant found in industrial effluents that is very toxic to humans and the environment. This study used pomegranate peel ash as a natural absorbent to remove phenol from aqueous solutions. Methods: In this study, pomegranate peel ash in different doses was used as a new adsorbent for the removal of phenol. The effects of contact time, pH, adsorbent dose and i...

ABSTRACT - Vermicomposting with pomegranate pulp can not only prevent pollution of the environment but can also create jobs, generate added value and prevent the waste of energy and the country's capital. This factorial experiment was conducted in a completely randomized design. The first factor (a) in two levels contained neutralized pomegranate pulp with lime and non-neutralized pulp. The sec...

BACKGROUND Polyphenols have received a great deal of attention due to their biological functions. Pomegranate (Punica granatum L.) is a polyphenol-rich fruit. In the past decade, studies testing the antimicrobial activity of pomegranates almost exclusively used solvent extracts instead of fresh pomegranate juice (FPJ). The use of FPJ instead of solvent extracts would reduce toxicity issues whil...

BACKGROUND Aqueous pomegranate seed extract (PSE), a by-product of the pomegranate juice industry, was recently identified as a potential antiglycative ingredient. Ellagic acid was proposed as the major polyphenol responsible for the antiglycative activity as exerted in in vitro models. However, there is no information on safety aspects of this extract in biological systems before its applicati...