This article has not been copyedited and formatted. The final version may differ from this version. ABSTRACT The ontogeny of the first four families of cytochrome P450s (Cyp1-4) can affect the biotransformation of drugs and dietary chemicals in liver resulting in unique pharmacological reactions in children. As genome-scale investigations have identified many novel Cyp isoforms recently, it is ...

Apolipoprotein E-null mice on a DBA/2J genetic background (DBA-apoE) are highly susceptible to atherosclerosis in the aortic root area compared with those on a 129S6 background (129-apoE). To explore atherosclerosis-responsible genetic regions, we performed a quantitative trait locus (QTL) analysis using 172 male and 137 female F2 derived from an intercross between DBA-apoE and 129-apoE mice. A...

Constraint Handling Rules (CHR) is a declarative concurrent programming language. Like the class of Concurrent Constraint (CC) languages, CHR features a declarative semantics based on Girard’s intuitionistic linear logic. The phase semantics of linear logic has been used in the past to prove safety properties for the class of CC languages. In this paper we show that we can adapt this result to ...

A grammar formalism based upon CHR is proposed analogously to the way Definite Clause Grammars are defined and implemented on top of Prolog. These grammars execute as robust bottom-up parsers with an inherent treatment of ambiguity and a high flexibility to model various linguistic phenomena. The formalism extends previous logic programming based grammars with a form of context-sensitive rules ...

Implementations of CHR follow a committed-choice forwardchaining execution model: the non-determinism of the abstract semantics is partly re ned with extra-logical syntactic convention on the program order and possibly notations for weighted semantics (with priorities or probabilities), and partly left unspeci ed in the underlying compiler. This paper proposes an alternative execution model whi...

OBJECTIVE The aim of this study was to evaluate the clinical significance of reticulocyte hemoglobin content (CHr) in the diagnosis of iron deficiency anemia (IDA) and to compare it with other conventional iron parameters. MATERIALS AND METHODS A total of 32 female patients with IDA (serum hemoglobin <120 g/L and serum ferritin <20 ng/ mL) and 18 female patients with iron deficiency (serum he...

BACKGROUND Some studies have shown that anxiety is particularly frequent in the Clinical High Risk (CHR) for psychosis population. Notably, social anxiety disorder is identified as one of the most common anxiety disorders in CHR adolescents and young adults. Despite this, the frequency and the clinical significance of social anxiety in this population have been underestimated. METHODS A selec...

Epidemiologic studies demonstrated an excess risk of ischemic heart disease (IHD) among individuals who simultaneously exhibit hypertension and elevated atherogenic lipids (coronary high risk (CHR)-status). Yet, relatively little is known about factors which contribute to the development of CHR-status during early and middle adulthood. The present study explores the role of selected biobehavior...

We report the construction of 17 recombinant inbred (RI) strains of mice derived from the progenitor strains NZB/BINRe and SM/J and the typing of this RI strain set, designated NXSM, for 58 loci distributed on 16 autosomes and the X chromosome. Two backcrosses involving NZB/BINJ and SM/J were constructed to confirm chromosomal assignments and determine gene orders suggested from NXSM RI strain ...

Constraint Handling Rules (CHR) is a committed-choice declarative language which has been originally designed for writing constraint solvers and which is nowadays a general purpose language. CHR programs consist of multi-headed guarded rules which allow to rewrite constraints into simpler ones until a solved form is reached. Many empirical evidences suggest that multiple heads augment the expre...