Human leukocyte antigens (HLA) are crucial components of host defense against microbial challenge but the associations of HLA types with oral infectious diseases have not been studied in detail. This prospective cross-sectional study examined associations of HLA-A, -B and -DRB1 types with common oral diseases in a healthy Swiss adult population. 257 subjects (107 m, 150 f, mean age: 43.5 yr; ra...

A30-year-old man, with no prior pathologic antecedent was admitted to the internal medicine department for a 3 month history of cough and bloody sputum. These symptoms occurred in the context of apyrexia, night sweating and 6 kilogram weight loss. On physical examination the patient appeared pale, BMI was 17 kg/m, crackles were heard in the left lung. The skin examination noted painful genital ...

To assess the association between polymorphisms of the IL-6 -174 G/C and Behçet's disease (BD) in Tunisian patients. DNA was extracted from blood samples taken from 43 Tunisian patients and 43 healthy controls. The polymorphisms were analyzed by PCR with the PCR-RFLP. No significant association was found between patients and controls concerning polymorphism of IL6 -174 G/C between the (allelic ...

OBJECTIVE To determine the type and frequency of clinical features of Behçet's disease in a population of Italian patients. METHODS We retrospectively studied 137 Italian patients (76 males and 61 females, age at onset 29.6 +/- 12.2 [mean +/- SD] years) seen consecutively in nine different referral centers. The duration of follow-up at study entry was 10.9 +/- 8.2 years. Virtually all patient...

Using an in vitro peptide stimulation strategy, two chimpanzees that were acutely infected by the hepatitis B virus (HBV) produced peripheral blood CTL responses to several HBV-encoded epitopes that are known to be recognized by class I-restricted CTL in acutely infected humans. One animal responded to three HBV peptides that, in humans, are restricted by HLA-A2; the other animal responded to t...

OBJECTIVES HLA-B51 is strongly associated with Behçet's disease (BD) in any ethnic background. We recently reported that another gene, Toll-like receptor-4 (TLR4) is also implicated in BD in a Japanese population. To confirm these results, we investigated polymorphisms in the TLR4 gene in Korean patients with BD. METHODS In this study, 119 patients with BD and 141 healthy controls were enroll...

The Leontief model is generally considered as belonging to the category of the production-prices models , aside of the Ricardian, Marxian and Sra aian models. This paper clearly demonstrates that this is a super cial point of view. As the Leontief model handles price indexes, it is over two periods: the Leontief price indexes solve the model for the base time period. The production-prices model...

European Federation for Immunogenetics (EFI) accredited tissue typing laboratories in Istanbul Medical Faculty, Department of Medical Biology has been accepted as the reference laboratory for the ‘External Quality Control Tests’ program among HLA laboratories in Turkey by the permission of Turkish Ministry of Health since 2004. The test systems performed for the determination of essential param...

In a recent article in this journal I pointed out that the harmonic oscillator potential used to model most experiments on Bose–Einstein condensation of atomic gases simplifies the numerical analysis. In this note I extend my previous analysis to allow for anisotropic confining potentials. This extension yields a better comparison with real experiments ~which are performed in anisotropic confin...

Central nervous system involvement in Behçet disease (BD) may be either parenchymal or nonparenchymal. Abnormal cerebrospinal fluid findings and parenchymal involvement are associated with a poorer prognosis. A self-antigenic role for HLA B51 has been postulated in the pathogenesis of BD. The sibling occurrence rate is 3.6%. Familial aggregation may be more pronounced among pediatric cases comp...