1. Abstract 2. Introduction 3. Materials and methods 3.1. Clinical Characteristics of Patients 3.2. Serum Collection 3.3. Tumor Cyst Fluid Collection 3.4. ELISA for TNF and stnf-r’s 3.5. Cytolytic Bioassay for TNF Activity and TNF Blocking Factor Activity 3.6. Immunohistochemical Staining of Astrocytoma Tissue Sample 3.7. Statistical Analysis 4. Results 4.1. Serum Levels of TNF and the 55 kda a...

Background: Apolipoprotein B-100 (apo B-100) stands as one of the largest proteins in humans. Its large size of 4536 amino acids hampers the production of X-ray diffraction quality crystals and hinders in-solution NMR analysis, and thus necessitates a domain-based approach for the structural characterization of the multi-domain full-length apo B. Results: The structure of apo B-17 (the N-termin...

environment or a more susceptible population? Thorax 1994; 49: 171–174. 9. Holgate ST. The epidemic of allergy and asthma. Nature 1999; 402 (6760 Suppl): B2–B4. 10. Holt PG, Macaubas C, Stumbles PA, Sly PD. The role of allergy in the development of asthma [review]. Nature 1999; 402: B12–B17. 11. Strachan DP, Harkins LS, Johnson ID, Anderson HR. Childhood antecedents of allergic sensitization in...

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M icrobes employ several catalytic strategies to transform conformationally f lexible peptide chains into rigidified scaffolds that possess antibiotic or toxin activity. Prominent examples include the biosynthesis of the -lactam antibiotics of the penicillin and cephalosporin families (1) and the maturation of vancomycin (2) where distinct structural modifications to the nascent peptide chains ...

The modern enterprise software stack—a collection of applications supporting bookkeeping, analytics, planning, and forecasting for enterprise data—is in danger of collapsing under its own weight. The task of building and maintaining enterprise software is tedious and laborious; applications are cumbersome for end-users; and adapting to new computing hardware and infrastructures is difficult. We...

Archival specimens of 25 pulmonary carcinoids including 15 cases of typical carcinoid, 9 atypical carcinoids, and 1 large-cell nenroendocrine carcinoma were analyzed for mutations in exons 5 to 8 of the p53 gene. Mutations were identified in 4 tumors, including 3 out of 15 (20%) typical carcinoids and the single large-cell neuroendocrine carcinoma, but none of the atypical carcinomas showed a m...

We present the MU-CSeq tool for the verification of multi-threaded C programs with dynamic thread creation, dynamic memory allocation, and pointer arithmetic. It is based on sequentializing the programs over the new notion of individual memory location unwinding (IMU). IMU is derived from the notion of memory unwinding that has been implemented in the previous versions of MUCSeq. The main conce...