In dissolving microneedle (DMN)-mediated therapy, complete and rapid delivery of DMNs is critical for the desired efficacy. Traditional patch-based DMN delivery, however, may fail due to incomplete delivery from insufficient skin insertion or rapid separation of microneedles due to their strong bond to the backing film. Here, we introduce the Troy microneedle, which was created by cyclic contac...

This paper proposes a new approach for solving a generalization of the task scheduling problem for articulated robots (either redundant or non-redundant), where the robot’s 2D environment is cluttered with obstacles of arbitrary size, shape and location, while a set of task-points are located in the robot’s free-space. The objective is to determine the optimum collision-free robot’s tip tour th...

The hot stamping of tailored properties is widely established in the automotive industry. However, unlike conventional press hardening, this technique designed to generate varying mechanical by controlling cooling rate locally. Current material models cannot accurately represent locally very different thermomechanical paths. This research aims address problem developing a new phase transformati...

A fluorescent supramolecular polymer was efficiently constructed by pillar[5]arene-based host-guest molecular recognition and zinc ion coordination.

DRLÍK MARTIN, PILKOVÁ ANNA, MUNK MICHAL, ŠVEC PETER: Modelling of domestic and foreign visitors’ behaviour at commercial bank website during the recent fi nancial crisis. Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2013, LXI, No. 7, pp. 2065–2070 The paper focuses on modelling of commercial bank website visitors’ behaviour. The authors analyse domestic and foreign ma...

Three-dimensional object detection plays a vital role in the field of environment perception autonomous driving, and its results are crucial for subsequent processes. Pillar-based 3D is method to detect objects by dividing point cloud data into pillars extracting features from each pillar. However, current pillar-based object-detection methods suffer problems such as “under-segmentation” false ...

BACKGROUND Fatigue is a common symptom of chronic hepatitis C virus (HCV) infection and a frequent side-effect of peginterferon/ribavirin (PR) therapy for HCV. This study evaluated the impact of adding the oral HCV NS3/4A protease inhibitor simeprevir to PR on patient-reported fatigue and health status among patients with chronic HCV genotype 1 infection enrolled in the Phase IIb PILLAR and ASP...