نتایج جستجو برای: azoles
تعداد نتایج: 1992 فیلتر نتایج به سال:
[This corrects the article DOI: 10.1371/journal.ppat.1005775.].
Sarocladium kiliense, formerly known as Acremonium kiliense (1), is a ubiquitous soil saprophyte commonly found in the environment and occasionally infecting humans (2). Its pathogenicity in immunocompetent patients is low and usually is related to inoculation of the fungus via a penetrating injury that often leads to a granuloma formation. However, the presence of underlying immunological diso...
Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi . However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition T. cytochrome CYP51, the target azoles, does not deliver sterile cure monotherapy. Looking for suitable combination partners we have selected set inhibitors sterol and sphing...
This review summarizes the data on stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) related compounds obtained by multipulse multinuclear 1H, 13C, 15N NMR spectroscopy quantum chemistry. The stereochemistry is a challenging topic theoretical research, as correct interpretation their chemical behavior biological activity depends unde...
چکیده ندارد.
The role of Aspergillus fumigatus 14alpha-sterol demethylase (Cyp51A) in azole drug susceptibility was assessed. Targeted disruption of cyp51A in azole-susceptible and -resistant strains decreased MICs from 2- to 40-fold. The cyp51A mutants were morphologically indistinguishable from the wild-type strain, retaining the ability to cause pulmonary disease in neutropenic mice.
In vitro interaction of anidulafungin with voriconazole was tested by a microdilution broth checkerboard technique and an agar diffusion method against 30 Aspergillus clinical isolates belonging to five different species. By using a complete inhibition endpoint, indifferent interactions were observed for 97% of the isolates by the checkerboard technique (FIC index from 0.5 to 2) and for 100% of...
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