A peptide of 27 amino acids, VDR(102-76), representing residues 76-102 immediately C-terminal to the second Zn finger of human vitamin D receptor (hVDR) was conjugated to fluorescein-labelled IgG using a bifunctional coupling reagent, m-maleimidobenzoyl n-hydroxysuccinimide. Upon microinjection into the cytoplasm of human osteosarcoma MG-63 cells, the chimeras accumulated in the nuclei. This tr...

http://www.sciencemag.org/cgi/content/full/301/5629/102 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/301/5629/102/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...

THERE is no universally accepted "best" method of treating an intra-ocular' foreign body apart from its extraction from the globe. The controversial points may be summed up as: (a) anterior or posterior route of extraction, (b) diathermy of scleral field or simple incision, (c) Haab or Mellinger type of giant magnet. An intra-ocular foreign body is a surgical emergency and it is important to ke...

Short-time variations in intensity of about 40 percent, with a period of the order of 100 days, have been reported for the quasistellar radio source CTA 102 at 32.5-centimeter wavelength. We have observed CTA 102 at 25.5-centimeter wavelength over a 67-day, period and have detected no significant variations of intensity.

RESULTS: In the wound bed, Keap1 siRNA treated mice decreased Keap1 gene expression (55.4 ± 22.9%; p=0.004) and protein expression (94 ± 0.42%; p=0.038) compared to controls. Downstream protein expression of Nrf2 increased (3.27 ± 1.63 fold; p=0.039). The expression of antioxidant genes, NQO-1 and MnSOD-1 increased (4.99 ± 0.1 fold; p=0.04 and 3.66 ± 0.2 fold; p=0.01, respectively). The express...

ventricular system can be manifested as changes in intracranial pressure (ICP) and thus affect the clinical findings. However, slow-growing lesions of a primary CNS origin located in clinically silent regions of the brain such as the frontal lobe may be present for years before detection. Autopsy diagnosis reveals that nearly 25% of patients who die of cancer had intracranial metastasis (Fig. 1...

Introduction ___________________________________________________________________________________________________________________________ 91 Semi-Empirical Approaches _______________________________________________________________________________________ 94 ms Change Detection ________________________________________________________________________________________________________ 96 SAR Data Fus...

A novel ligand for the nociceptin/orphanin FQ (N/OFQ) receptor (NOP), [(pF)Phe(4),Arg(14),Lys(15)]N/OFQ-NH(2) (UFP-102), has been generated by combining in the N/OFQ-NH(2) sequence two chemical modifications, [Arg(14),Lys(15)] and [(pF)Phe(4)], that have been previously demonstrated to increase potency. In vitro, UFP-102 bound with high affinity to the human NOP receptor, showed at least 200-fo...