PURPOSE To investigate the refractive and biometric changes associated with adult-onset and adult-progression of myopia in an occupational group. METHODS The sample population consisted of 251 clinical microscopists aged 21 to 63 years. Subjects had their refraction and ocular dimensions measured on four occasions during a 2-year period, and a total of 166 subjects (332 eyes) completed the lo...

PURPOSE To investigate the relationship between myopia and macular thickness, as measured by optical coherence tomography. METHODS A total of 143 normal subjects comprising 80 eyes with high myopia (spherical equivalent [SE] < -6.0 D), 37 eyes with low to moderate myopia (SE between -6.0 and -0.5 D), and 26 nonmyopic eyes (SE > -0.5 D) were analyzed in this cross-sectional study. Total averag...

PURPOSE To group eyes in our refractive surgery unit on the basis of the origin of their ametropia and to assess the percentage of eyes in the different groups. METHODS Refractive parameters and the axial eye length (AL) of 131 eyes of 131 persons with different refraction were measured. The eyes were initially classified into five groups on the basis of the grade of their ametropia: hypermet...

PURPOSE To examine the association of myopia with the visual field (VF) defects in open-angle glaucoma (OAG) using paired eyes to eliminate the effect of unknown confounding factors that are diverse among individuals. METHODS One hundred eighteen eyes of 59 subjects with myopia (spherical equivalent [SE] ≥ -2 diopter [D] and axial length ≥ 24.0 mm) whose intra-ocular pressure between paired e...

This study aimed to investigate the refractive state and optical compositions of preterm children with and without mild retinopathy of prematurity (ROP) and explore the influence of prematurity and mild ROP on the development of refractive state and optical compositions.Preterm children who received fundus screening were recruited, and divided into ROP group and non-ROP group. Term children mat...

Purpose : to compare anatomical and optical parameters aberrations of both eyes in patients with acquired congenital anisometropic myopia. Material methods . 22 (44 eyes) aged 18–35 (averagely, 25.2) myopia were examined using the Galilei G6 eye system analyzer (Ziemer, Switzerland). The analysis total, corneal internal was carried out on an OPD-Scan III (Nidek) aberrometer. Results In groups m...

PURPOSE To determine the incidence and progression rates of myopia in young Singaporean children. METHODS A prospective cohort study, the Singapore Cohort Study of the Risk Factors for Myopia (SCORM), was conducted in two schools in Singapore (1999-2002). Children aged 7 to 9 years (n=981) were followed up over a 3-year period. Cycloplegic autorefraction and biometry parameter measures were p...

The mouse model has been widely employed to explore the mysteries of myopia. For now, existing techniques for induction of experimental myopia in mice can be classified into three types: (1) devices directly glued to the fur; (2) devices attached using a combination of glue and sutures; (3) devices attached using a skull-mounted apparatus. These techniques each have its advantages, disadvantage...

PURPOSE To evaluate the efficacy of a combined macular buckle under direct vision and 23-gauge pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling in refractory macular hole retinal detachment (MHRD) with extreme high axial myopia. DESIGN Prospective, randomised controlled study. PARTICIPANTS The study included 98 eyes of 98 patients of MHRD with extreme high axial (>3...

PURPOSE To investigate whether the Sonic hedgehog (Shh) signaling induces myopic development by increasing the expression of matrix metalloproteinase (MMP)-2 in guinea pigs. METHODS A translucent diffuser was glued onto the right eye to induce form-deprivation myopia (FDM) in 10 guinea pigs. Four guinea pigs were served as a control group. The other 100 guinea pigs were subdivided into 5 grou...