BACKGROUND Thrombopoietin (TPO), the major hormone controlling platelet production, has been measured in thrombocytopenias with discordant results. The aim of our work was to assess the value of the TPO assay for differential diagnosis of thrombocytopenias in a large cohort of patients classified according to the results of their platelet isotopic study. METHODS We measured TPO (R&D Systems) ...

BACKGROUND Post-transfusion purpura is a rare syndrome characterized by severe thrombocytopenia and bleeding caused by alloimunization to human platelet specific antigens following a blood component transfusion. The suggested incidence is 1:50,000-100,000 transfusions, most often occurring in multiparous women. The diagnosis is not easy because these patients, who are often critically ill or po...

Thrombocytopenia is likely the most common and prevalent haematological abnormality that can be found in patients affected by chronic liver disease [1]. A recent systematic review has shown that, in patients chronically infected with the hepatitis C virus (HCV), the prevalence of thrombocytopenia may vary from 0.16% in a cohort study that identified patients with severe autoimmune cytopenia alo...

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with a variety of clinical manifestations related to viral tissue damage, as well virally induced immune response. Hyperstimulation the system can serve trigger for autoimmunity. Several immune-mediated have been described in course SARS-CoV-2 infection. Immune thrombocytopenic purpura (ITP) and autoimmune hemo...