Over the past decade, relevant improvements and refinements have significantly changed the indications, technique and results obtained with allogeneic transplantation of hematopoietic stem cells (HSC) in childhood. In this review the most important innovations that have characterized the practice of HSC transplantation in childhood during this decade will be discussed. We will analyze the clini...

Men with testicular failure, either primary or secondary, have been shown to be interested in fertility preservation. Spermatogonial stem cell (SSC) transplantation is currently being investigated as a treatment for this. Currently this experimental technique consists of cryopreservation of a testicular biopsy prior to cancer treatment, followed by optional in vitro expansion of SSCs and auto t...

Posterior reversible encephalopathy is a complex but well-recognized clinical and radiological entity associated with a variety of benign and malignant conditions including hypertensive encephalopathy, eclampsia, renal failure and immunosuppressive drugs. The pathogenesis is incompletely understood, although it seems to be related to the breakthrough of auto-regulation and endothelial dysfuncti...

Ectopic splenic tissue may be congenital or acquired. Splenules can result from trauma or, less frequently, splenectomy, in which splenic parenchyma seeds accessible tissue to subsequently develop ectopic splenic tissue. This process of auto-transplantation is known as splenosis. Splenosis is a rare, benign condition most often found incidentally on imaging.1 Here, we describe a patient with a ...

BACKGROUND The risk-benefit ratio of cyclosporine A (CsA) is much more critical in some auto-immune diseases in comparison to transplantation medicine, due to its renal toxic potential. The present meta-analysis is based on an a priori defined methodology, and is linked with a review of CsA-induced morphological lesions, in order to draw relevant conclusions with regard to CsA-induced nephrotox...

Thomas Karcher Institute for Program Structures and Data Organization Karlsruhe Institute of Technology 76128 Karlsruhe, Germany [email protected] Christopher Guckes Institute for Program Structures and Data Organization Karlsruhe Institute of Technology 76128 Karlsruhe, Germany [email protected] Walter F. Tichy Institute for Program Structures and Data Organization Karlsruhe Institute...

Although high-dose chemotherapy is the gold standard for the treatment of many relapsed or refractory lymphomas, the outcome remains unsatisfactory, particularly in some subsets of patients with adverse prognostic features. Here we report the outcome of 111 high-risk lymphoma patients treated with a tandem strategy involving debulking with HDC followed by autologous stem cell transplantation (A...

Service-oriented architectures (SOA) and, in particular, Web Services designs are widely adopted for the development of interoperable systems. In a dynamic scenario, a composed service may exploit component services in order to complete its task; composed services are variously distributed, and offered by different providers in different security domains and under different load conditions. So,...