Wound healing succeeds tissue destruction. We hypothesized that antibodies might bind to wounded tissues, which would facilitate the engulfment of damaged tissues by macrophages. We detected the autoantibodies in sera of different ages of mice, which bind to wounded tissues. We detected IgG1 binding to wounded tissues by using FITClabeled anti-IgG1 in C57BL/6 mice. These bands were highest in 4...

Until recently it has been assumed that the autoantibodies found in acquired haemolytic anaemia are non-specific; that is to say they react with all types of human red cells and are unrelated to any known blood group antibodies. However, Weiner, Battey, Cleghorn, Marson, and Meynell (1953) have described a patient in whom the auto-antibody had the specificity anti-e, the patient's red cells hav...

A wide range of autoantibodies have been described in immune-mediated nerve disorders that target glycans borne by glycolipids and glycoproteins enriched in the peripheral nerves. Their use as diagnostic biomarkers is very widespread, despite some limitations on sensitivity and specificity, and the lack of standardized assays and access to quality assurance schemes. Although many methods have b...

A utoimmunity is a common mechanism underlying many common human diseases. Although the mechanisms are not well understood, autoimmunity is thought to arise from a failure in self-tolerance, resulting in a sustained immunological attack by specifi c antibody, T cells, or both, directed against antigens within the target tissues or organs [1]. Many autoimmune disorders appear to have a genetic b...

Anti-cytokine therapeutic antibodies have been demonstrated to be effective in the treatment of several auto-immune disorders. However, The problems in antibody manufacture and the immunogenicity caused by multiple doses of antibodies inspire people to use auto-cytokine as immunogen to induce anti-cytokine antibodies. Nevertheless, the tolerance for inducing immune response against self-antigen...

Clinically relevant joint destruction has now become infrequent in patients with newly diagnosed rheumatoid arthritis (RA), while other disease outcomes such as functional ability and disease persistence have become more important. Recently, novel auto-antibody reactivities have been identified in RA, with the ultimate aim to better characterise patients with RA. Anticarbamylated protein (anti-...

A humoral immune response against aberrant tumor proteins can be elicited in cancer patients, resulting in the production of auto-antibodies (Abs). By serological proteome analysis we identified the surface membrane protein ADAM10, a metalloproteinase that has a role in epithelial-tumor progression and invasion, as a target of the immune response in colorectal cancer (Crc). A screening carried ...

There is evidence that there is an association between anti-glomerular basement membrane (anti-GBM) antibodies and anti-neutrophil cytoplasmic antibodies (ANCA) in the development of pulmonary renal syndrome (PRS) [1–7]. Whether these two distinct circulating auto-antibodies have some pathological interaction remains unclear. Studies have shown that 30% of patients with anti-GBM disease will te...

Myelin oligodendrocyte glycoprotein (MOG) is an antigen of the myelin sheath, which may trigger immune cell responses and the production of auto-antibodies in multiple sclerosis (MS). In this study, we used MOG(35-55) -induced experimental autoimmune encephalomyelitis (EAE), a model of human MS, to assess the production of catalytically active immunoglobulin G (IgG) antibodies or abzymes which ...