A quantitative colorimetric sensing strategy utilizing cysteamine modified gold nanoparticles (CA-AuNPs) as reporters for Hg(2+) and melamine was demonstrated. Cysteamine is a cheap and commercially available aminothiol and is also the most important chelating ligand in coordination chemistry possessing the ability to coordinate to Hg(2+) and melamine. The terminal thiol group in cysteamine is ...

We describe a simple, yet selective cysteine sensor based on gold nanoparticles (AuNPs) conjugated with thermoresponsive copolymers, the carboxyl groups of which are incorporated. Copolymer-conjugated AuNPs, used as the cysteine sensor, in a solution form sediment when cysteine is added. Heating followed by cooling the solution induces phase transitions of the thermoresponsive copolymers, resul...

Gold nanoparticles (AuNPs) coated with a diblock copolymer composed of poly(ethylene oxide) (PEO) and poly(N,N-dimethylaminoethyl methacrylate) (PEO-b-PDMAEMA) were prepared, while their reaction with 1,3-propane sultone gave rise to quaternized PEO-b-PDMAEMA chains on AuNPs. Using pyrene as a probe equilibrated with polymer-coated AuNP aqueous solutions, the fluorescence measurement results sh...

Gold nanoparticles were synthesized using a water extract of Artemisia capillaris (AC-AuNPs) under different extract concentrations, and their catalytic activity was evaluated in a 4-nitrophenol reduction reaction in the presence of sodium borohydride. The AC-AuNPs showed violet or wine colors with characteristic surface plasmon resonance bands at 534~543 nm that were dependent on the extract c...

The sputter deposition of metals in an ionic liquid (IL) capture medium is a simple and elegant method for preparing nanoparticles without any chemical reaction. Although there have been some reports on the size determination factors for Au nanoparticles (AuNPs) prepared using this method, the effects with respect to the type of IL used have not been clearly elucidated. This is because there ar...

While the immunogenicity and cytotoxicity of gold nanoparticles (AuNPs) are noted by many researchers, the mechanisms by which AuNPs exert these effects are poorly understood. In this study, we investigated the effects of polyethylene glycolylated AuNPs (PEG@AuNPs) on lipopolysaccharide (LPS)-induced nitric oxide (NO) and interleukin-6 (IL-6) production and the associated molecular mechanism in...

UNLABELLED The present study characterized the in vitro biological response of a comprehensive set of cancer cell lines to gold nanoparticles (2.7 nm) coated with tiopronin (AuNPs-TP). Our findings suggest that upon entering cells, the AuNPs-TP are sequestered in vacuoles such as endosomes and lysosomes, and mostly localize in perinuclear areas. Peak cell accumulation was achieved at 8 hours af...

This study describes a novel fabrication technique to grow gold nanoparticles (AuNPs) directly on seeded ZnO sacrificial template/polymethylsilsesquioxanes (PMSSQ)/Si using low-temperature hydrothermal reaction at 80°C for 4 h. The effect of non-annealing and various annealing temperatures, 200°C, 300°C, and 400°C, of the ZnO-seeded template on AuNP size and distribution was systematically stud...

Gold nanoparticles (AuNPs) have been extensively employed in biological studies for several decades. More recently, progress has well demonstrated that DNA-conjugated AuNPs are highly promising nanoprobes for the sensitive detection of various biomolecules, based on the unique optical and electronic properties of AuNPs. In this short review, we focus on the use of AuNP-based nanoprobes for biol...

BACKGROUND Reproducibly high transfection rates with low methodology-induced cytotoxic side effects are essential to attain the required effect on targeted cells when exogenous DNA is transfected. Different approaches and modifications such as the use of nanoparticles (NPs) are being evaluated to increase transfection efficiencies. Several studies have focused on the attained transfection effic...