OBJECTIVE To identify the clinical pattern of symptomatic ocular tuberculosis (OTB) and the outcome following antitubercular therapy (ATT) in an endemic setting. DESIGN A descriptive case series. SETTING Tuberculosis and ophthalmology clinics, Teaching Hospital, Kandy, Sri Lanka. METHOD We followed up patients with OTB on standard six-month regimen of ATT, from January 2006 to December 20...

Previous research has shown that an increase in hamstring activation may compensate for anterior tibial transalation (ATT) in patients with anterior cruciate ligament deficient knee (ACLd); however, the effects of this compensation still remain unclear. The goals of this study were to quantify the activation of the hamstring muscles needed to compensate the ATT in ACLd knee during the complete ...

Pyridoxal phosphate (PLP), a bioactive form of pyridoxine, dose-dependently (10-1000 microm) inhibited cell proliferation in rat pituitary MMQ and GH3 cells and in mouse AtT-20 cells. After 4 d, MMQ cell numbers were reduced by up to 81%, GH3 cell numbers were reduced by up to 64% (P < 0.05), and AtT-20 cell numbers were reduced by up to 90%. Cell proliferation rates recovered and dose-dependen...

Mutant cancer-driving oncogenes are the best therapeutic targets, both with drugs like small-molecule inhibitors (SMI) and adoptive T-cell therapy (ATT), the most effective form of immunotherapy. Cancer cell survival often depends on oncogenes, which implies that they are homogeneously expressed by all cancer cells and are difficult to select against. Mutant oncogene-directed therapy is relativ...

Average trapping time (ATT) is central in the trapping problem since it is a key indicator characterizing the efficiency of the problem. Previous research has provided the scaling of a lower bound of the ATT for random walks in general networks with a deep trap. However, it is still not well understood in which networks this minimal scaling can be reached. Particularly, explicit quantitative re...

Manuscript received January 20, 2012; revised march 29, 2012; accepted April 17, 2012. 7 The authors are with the Spanish Institute for Sustainable Agriculture, CSIC, Apartado 4084, 14080-Cordoba, Spain (e8 mail: [email protected] ). 9 10 11 Abstract--Geo-referencing of remote imagery with high spatial resolution can be achieved using the 12 semi-AUtomatic GEO-referencing (AUGEO) system which ...

OBJECTIVE To determine the frequency of common risk factors for multi-drug resistant tuberculosis in patients presented at a tertiary care hospital, Peshawar. STUDY DESIGN Cross-sectional, observational study. PLACE AND DURATION OF STUDY Pulmonology Department, Khyber Teaching Hospital, Peshawar, from December 2006 to October 2007. METHODOLOGY Patients with positive AFB culture and sensit...

OBJECTIVES Optimal therapy for patients with non-small cell lung carcinoma (NSCLC) presenting with synchronous brain-only oligometastases (SBO) is not well defined. We sought to analyze the effect of differing therapeutic paradigms in this subpopulation. MATERIALS AND METHODS We retrospectively analyzed NSCLC patients with 1-4 SBO diagnosed between 1/2000 and 1/2011 at our institution. Patien...

The information society, having a growing information domain/amount, requires a reliable information infrastructure with ability to distribute the right information from the right information producer to the right information consumer, at the right time and with the right quality on demand (information-on-demand). Another growing demand, parallel with the information distribution infrastructure...

Synchronized moving aperture radiation therapy (SMART) is a new technique for treating mobile tumours under development at Massachusetts General Hospital (MGH). The basic idea of SMART is to synchronize the moving radiation beam aperture formed by a dynamic multileaf collimator (DMLC) with the tumour motion induced by respiration. SMART is based on the concept of the average tumour trajectory (...