Experiments were performed in vivo on chronically cannulated adult rainbow trout (Oncorhynchus mykiss) to assess the involvement of serotonergic or muscarinic receptor stimulation or activation of the renin-angiotensin system in eliciting catecholamine release during acute hypoxia during periods of nicotinic receptor desensitisation. Despite nicotinic receptor desensitisation induced by intrave...

Thymoquinone (TQ) is a bioactive component found in many medicinal herbs. In this study, we report the smooth and cardiac muscle relaxant activities of this compound. TQ concentration dependently suppressed spontaneously contracting rabbit jejunum while also relaxed high K(+)-(80 mM) induced contractions in jejunum and guinea-pig ileum, indicating activity at voltage-operated Ca(++) channels (V...

BACKGROUND Surgical conditions in laparoscopic surgery are largely determined by the depth of neuromuscular relaxation. Especially in procedures that are confined to a narrow working field, such as retroperitoneal laparoscopic surgery, deep neuromuscular relaxation may be beneficial. Until recently, though, deep neuromuscular block (NMB) came at the expense of a variety of issues that conflicte...

Galinsky R, Lear CA, Yamaguchi K, Wassink G, Westgate JA, Bennet L, Gunn AJ. Cholinergic and -adrenergic control of cardiovascular reflex responses to brief repeated asphyxia in termequivalent fetal sheep. Am J Physiol Regul Integr Comp Physiol 311: R949–R956, 2016. First published September 16, 2016; doi:10.1152/ ajpregu.00340.2016.—The role of cholinergic and -adrenergic activity in mediating...

OBJECTIVE We tested the hypothesis that adrenergic activation, cholinergic activation, or both, mediate the effect of recent antecedent hypoglycemia to reduce the sympathoadrenal response to subsequent hypoglycemia, the key feature of hypoglycemia-associated autonomic failure in diabetes, in humans. RESEARCH DESIGN AND METHODS Seventeen healthy adults were studied on 2 consecutive days on thr...

BACKGROUND AND OBJECTIVES Thoracic epidural blockade is a method of hypotensive anesthesia able to reduce bleeding during surgery. This non-comparative study aimed at evaluating the results of thoracic epidural blockade with 0.5% ropivacaine associated to propofol continuous infusion sedation in plastic surgery. METHODS Participated in this study 60 female patients aged 18 to 62 years, physic...

We have observed that in chloralose-anesthetized animals, gastric distension (GD) typically increases blood pressure (BP) under normoxic normocapnic conditions. However, we recently noted repeatable decreases in BP and heart rate (HR) in hypercapnic-acidotic rats in response to GD. The neural pathways, central processing, and autonomic effector mechanisms involved in this cardiovascular reflex ...

The interest in tropane alkaloids (TA) as food contaminants is increasing. A sensitive and selective LC-MS/MS method was applied for the analysis of corn puff samples from Serbian market. Only atropine quantified 22% samples. In case scopolamine, although not quantified, it detected Whether acute reference dose (ARfD) could be exceeded checked on a case-by-case basis individual products under a...

There is no consensus oti the effect of slow pathway ablation on the electrophysiologic properties of the fast pathway in patients with AV ncxial reentrant tachycardia. Some investigators have demonstrated that ahlation of the slow pathway results In shortening of the fast pathway effective refractory period, while other investigators have not made this observation.' '̂ In the setting of sympath...

Organophoshorous poisoning is a common cause of death in developing countries. These compounds inhibit acetylcholinesterase leading to accumulation acetylcholine, causing overstimulation nicotinic and muscarinic receptors. Atropine oximes are the mainstay treatment. helps countering effects decreasing secretions. It also makes secretions thick, tenacious may obstruct airway. We observed five ca...