seventy seven adult large mixed breed dogs of either sex were included in this study. the animals were randomly divided into four groups and received the following drug combinations intramuscularly: group 1 xylazine (0.5 mg/kg) and acepromazine (0.05 mg/kg), group 2 xylazine (0.8 mg/kg) and acepromazine (0.03 mg/kg), group 3 xylazine (0.3 mg/kg) and acepromazine (0.08 mg/kg) and group 4 xylazin...

The effects of various cholinergic agonists and antagonists and their interactions were determined on the awake-sleep cycle of cats with chronic indwelling brain electrodes. The effects were measured by the use of the EEG and correlated with gross behavioral observation. EEG recordinxs were taken from various neocortical and limbic structures, ~cluding the amygdala and hi~pocampus. EEG activati...

PURPOSE Our previous study, Atropine for the Treatment of Myopia 1 (ATOM1), showed that atropine 1% eyedrops were effective in controlling myopic progression but with visual side effects resulting from cycloplegia and mydriasis. The aim of this study was to compare efficacy and visual side effects of 3 lower doses of atropine: 0.5%, 0.1%, and 0.01%. DESIGN Single-center, double-masked, random...

The effects of atropine and metoclopramide on the lower oesophageal sphincter pressure (LOSP) were studied in 12 healthy volunteers using oesophageal pressure transducers. Atropine decreased LOSP significantly at 5 min after i.v. injection (P less than 0.005) and this change was sustained for 60 min. Metoclopramide increased LOSP significantly at 3 min after administration i.v. (P less than 0.0...

Background: Atropine is the most commonly used pharmacologic agent as a cycloplegic and mydriatic. Taken into account current economical burden worldwide, the well-known drugs are “reincarnated’ and repurposed. In this light of view atropine is highlighting new properties and new target in modern ophthalmology. Objective: The objective of this review is to evaluate the evidence and discuss the ...

PURPOSE To investigate whether seasonal modification in the concentration of atropine drops is effective in retarding the progression of myopia. METHODS Two hundred and forty eyes of 120 healthy preschool- and school-age children in Chiayi region, Taiwan were recruited. The treatment group consisted of 126 eyes of 63 children who received atropine eye drops daily for one year and the control ...

AIMS To assess the efficacy of a new regimen of intravenous atropine treatment for infantile hypertrophic pyloric stenosis (IHPS) with special reference to regression of pyloric hypertrophy. METHODS Atropine was given intravenously at a dose of 0.01 mg/kg six times a day before feeding in 19 patients with IHPS diagnosed from radiographic and ultrasonographic findings. When vomiting ceased and...

Fifty-six patients with acute myocardial infarction complicated by sinus bradycardia (SB) were treated with intravenous atropine and monitored in a coronary care unit. Atropine decreased or completely abolished premature ventricular contractions (PVCs) and/or bouts of accelerated idioventricular rhythm in 27 of 31 patients (87%) and brought systemic blood pressure up to normal in 15 of 17 patie...

men. Methods and Results. Responses to two 5-minute intravenous isoproterenol infusions (0.01 ug/kg/min and 0.02 pg/kg/min) were evaluated in six type A and six type B men after pretreatment with either dextrose placebo or atropine (1.2 mg). Atropine significantly potentiated T wave attenuation in the recovery period after isoproterenol infusion (0.30±0.07 mV) compared with placebo (0.54±0.09 m...

The effect of atropine, a muscarinic cholinergic blocking agent, on the response of plasma pancreatic polypeptide (hPP) to the ingestion of beef was investigated. Six healthy subjects ingested 250 g broiled ground beef on three occasions. After beef ingestion alone, the expected biphasic plasma hPP response was observed. On the two other occasions atropine (intravenous bolus followed by infusio...