Gastric biopsies from 1477 participants in a chemoprevention trial for precancerous lesions of the stomach in Venezuela were evaluated for the prevalence of precancerous lesions and Helicobacter pylori infection. These study subjects were selected from participants in an early detection program for gastric cancer using double-contrast X-ray. Overall, 94% had some type of chronic gastritis (CG) ...

Gastric cancer (GC) is one of the leading causes of cancer related death in the world, particularly in East Asia. According to the Correa's cancer cascade, non-cardia GC is usually developed through a series of mucosal changes from non-atrophic gastritis to atrophic gastritis (AG), intestinal metaplasia (IM), dysplasia and adenocarcinoma. Atrophic gastritis and IM are therefore generally consid...

BACKGROUND/AIMS The characteristics of pepsinogen screening for gastric cancer were investigated to establish a suitable cut off point for identifying gastric cancer, using endoscopic diagnosis as the yardstick. SUBJECTS/METHODS Serum pepsinogen concentrations were measured in 5113 subjects who were also screened for gastric cancer by endoscopy. The cut off point for pepsinogen was determined...

BACKGROUND Although accumulating evidence suggests that Helicobacter pylori plays a role in gastric carcinogenesis, the magnitude of the risk remains uncertain. AIM We aimed to estimate the magnitude of the risk of gastric cancer associated with H. pylori infection by a large case-control study nested within a prospective cohort. Possible effect modification by CagA status, and serum pepsinog...

it is now well known that chronic atrophic gastritis may occur in patients who do not have Addisonian pernicious anaemia, and that the histological appearance of the gastric mucosa in patients with and without pernicious anaemia may be indistinguishable. In fact there is no pathognomonic histological gastric lesion in pernicious anaemia (Magnus, 1958; Williams, Coghill, and Edwards, 1958). Furt...

it is now well known that chronic atrophic gastritis may occur in patients who do not have Addisonian pernicious anaemia, and that the histological appearance of the gastric mucosa in patients with and without pernicious anaemia may be indistinguishable. In fact there is no pathognomonic histological gastric lesion in pernicious anaemia (Magnus, 1958; Williams, Coghill, and Edwards, 1958). Furt...

AIMS To assess the prevalence of gastric giardiasis in patients undergoing upper gastrointestinal endoscopy, and to define the clinicopathological correlates of gastric Giardia lamblia infection. METHODS Consecutive gastric biopsy specimens (n = 15,023) from 11,085 patients, taken at Feltre City Hospital (north eastern Italy) from January 1986 to December 1991, were histologically and immunoc...

Gastric cancer remains a leading cause of cancer-related deaths in many parts of the world. At present, prevention seems to be the most effective means to reduce its the incidence and mortality rate. Gastric atrophy is considered the first relevant step in the histogenesis of gastric adenocarcinoma. However, whether screening for and surveillance of atrophic gastritis is advisable is debated. T...

Chronic Helicobacter pylori infection produces several lesions in the human stomach, which can progress to chronic atrophic gastritis and gastric cancer. To date, there is very little information on gene expression its relationship with progression In this study, we performed a analysis during order identify possible biomarkers that allow an early diagnosis of We studied biopsies from patients ...

BACKGROUND Decreased density of H. pylori in atrophic gastritis may lead to low sensitivity of the routine tests. AIMS To evaluate the accuracy of routinely used H. pylori tests in atrophic gastritis. METHODS We compared 5 H. pylori diagnostic tests in 119 dyspeptic patients (28 males/91 females) with a mean age of 67 years (range 55-84). Patients with gastric cancer, peptic ulcer, previous...