From March 1996 to August 1997, a study was carried out in a malaria endemic area of the Brazilian Amazon region. In vivo sensitivity evaluation to antimalarial drugs was performed in 129 patients. Blood samples (0.5 ml) were drawn from each patient and cryopreserved to proceed to in vitro studies. In vitro sensitivity evaluation performed using a radioisotope method was carried out with the cr...

CONTEXT Many US clinicians and laboratory personnel are unfamiliar with the diagnosis and treatment of malaria. OBJECTIVES To examine the evidence base for management of uncomplicated and severe malaria and to provide clinicians with practical recommendations for the diagnosis and treatment of malaria in the United States. EVIDENCE ACQUISITION Systematic MEDLINE search from 1966 to 2006 usi...

Abstract The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy threatens the global malaria elimination campaign. By applying systems-based quantitative transcriptomics, proteomics, metabolomics to a panel isogenic K13 mutant or wild-type P. lines, we provide evidence that alter multiple aspects parasite’s int...

PATIENT Male, 52 FINAL DIAGNOSIS: L-asparaginase associated steatohepatitis and pulmonary Pneumocystis Symptoms: Cholestasis • hepatomegaly MEDICATION Corticosteroids • atovaquone • antioxidant therapy Clinical Procedure: Liver biopsy Specialty: Hematology • Infectious Disease • Hepatology. OBJECTIVE Challenging differential diagnosis. BACKGROUND L-asparaginase (L-aspa) is an important co...

Phillips and Lampe [1]. Given the rapid changes in HAART over the past decade— including marked improvements in potency, tolerability, and dosing frequency, it is doubtful that we will ever have an observational cohort in which patients receive the same therapy for 10 years. New therapies are certain to emerge that will be adopted, and the details of the research questions will change over time.