Obesity and insulin resistance are both associated with an atherogenic lipoprotein profile. We examined the effect of insulin sensitivity and central adiposity on lipoproteins in 196 individuals (75 men and 121 women) with an average age of 52.7 years. Subjects were subdivided into three groups based on BMI and their insulin sensitivity index (S(I)): lean insulin sensitive (n = 65), lean insuli...

This study was designed to determine the effect of regression of atherosclerotic lesions on the incorporation of l-C-oleic acid into phospholipids, triglycerides, and cholesteryl esters and to compare these metabolic alterations with changes in the extent of atherosclerosis and the content of cholesterol and cholesteryl esters in the lesions. Aortic atherosclerosis was produced in White Carneau...

OBJECTIVE: To investigate the role of dietary carbohydrate in atherogenesis. METHOD: Search of the literature for relevant papers concerning the relationship of insulin/hyperinsulinemia and carbohydrate on the one hand, and the renin-angiotensin system, the sympathetic nervous system, growth factors, i.e. platelet-derived growth factor and insulin-like growth factor-I, C-reactive protein, and d...

So far, little is known about the effect of nutrition and lifestyle on the composition of circulating lipoprotein subfractions. In the current study, we measured the correlations among physical activity, nutrient intake, smoking, body-mass index (BMI), and age with the concentration of triglycerides, cholesterol, phospholipids, and apolipoproteins (ApoA1, ApoA2 and ApoB) in subfractions of LDL ...

BACKGROUND The apolipoprotein (apo) B/apoA-I ratio represents the balance between apoB-rich atherogenic particles and apoA-I-rich antiatherogenic particles, and this ratio is considered to be a marker of cardiovascular risk. Although many studies have demonstrated the importance of the apoB/apoA-I ratio in predicting the presence or absence of cardiovascular disease, less is known about apoB/ap...

Cardiovascular diseases with an incidence of approximately 50% are the main causes of death in most advanced countries and an increasing trend in the developing world as well. The World Health Organization estimates that 12 million people per year worldwide die from cardiovascular diseases. Cardiovascular diseases are becoming an increasing problem worldwide and hypercholesterolemia has been co...

BACKGROUND Oxidative stress (OS) generated by hyperglycemia, is one of the major focuses of recent research related to diabetes mellitus. Studying associations between hyperglycemia, OS and atherogenic dyslipidemia (AD) is therefore important. MATERIALS AND METHODS Plasma was obtained form a total of 52 subjects with newly diagnosed Type 2 diabetes mellitus (T2DM) and 52 healthy controls to s...

Utilizing the stumptail macaque, we studied the atherosclerotic lesions produced in the aorta and coronary arteries by an atherogenic diet alone and by the diet coupled with hypertension produced by a modified Goldblatt technique. One group of monkeys was subjected concomitantly to the diet and hypertension for 10-12 months; a second group was on the diet for 29-32 months, but hypertension was ...