background: mitochondria are autonomous cellular organelles that oversee a variety of functions such as metabolism, energy production, calcium buffering, and cell fate determination. most recently, mitochondrial dysfunction caused by mitochondrial mutations played important roles in the pathogenesis of asthma. however, the frequency of mitochondrial trna mutations in asthma is largely unknown. ...

asthma is a heterogeneous disease, in which asthmatic patients present with different clinical phenotypes, variable endotypes, and different response to asthma medicines. thus, we are faced with an asthma paradox; asthma is diagnosed subjectively by clinical history and treated with biologically active drugs. to solve this paradox, we need objective airway biomarkers to tailor the proper medica...

several asthma susceptibility loci, including a region containing the vitamin d receptor (vdr) gene located at chromosome 12q, have been identified using genome-wide screens. our aim is to investigate the association between single nucleotide polymorphisms (snps) in vdr gene and asthma. one hundred one asthma patients and 206 healthy controls were enrolled in this study. genotypes were determin...

asthma and allergic diseases present a major health burden. information on the prevalence of these diseases indicates that these diseases are increasing in various parts of the world. it was hoped that this study would be helpful to health system policy-makers in planning allergy prevention programs in the region.the prevalence of asthma and allergic diseases and relation between the various ri...

asthma is the most common chronic respiratory disease of children in the world. serial studies in the world have showed an increased prevalence of bronchial asthma. in this study, the children younger than 12 years old referred to jahrom hospital and clinic due to asthma were selected. we issued 100 questionnaires, according to international study of asthma and allergies in childhood (isaac) cr...

abstract asthma is a common chronic inflammatory and complex disease in children with many contributing (including genetic and environmental) factors. this study aims to review the impact of infections in children with asthma. different websites including googlescholar, yahoo, pubmed, sid.ir, magiran, irandoc, iranmedex ,embase and hand searching were searched for pertinent articles with keywor...

introduction: the coexistence of asthma and chronic rhinosinusitis (crs) is more common than expected given their individual prevalence in the general population and may affect patient’s quality of life. the aim of this study was to evaluate the prevalence of asthma in chronic rhinosinusitis in mashhad, northeast iran.  materials and methods: this study was performed in two university hospital ...

interleukin-12 (il-12) is a key cytokine involved in regulating the balance between th1 and th2 cells by promoting th1 response. a reduced capacity to produce this cytokine could lead to aberrant th2 development. on the same aspect significant impact of il-12 on invariant natural killer t (inkt) cells was reported. therefore, we examined the serum levels of il-12 and the absolute number of peri...

assesment of health related quality of life (hrql) is increasingly recognized as an important part of the patient care in asthma. we aimed to evaluate the effect of personality disorders (pds) on hrql and the severity of disease in asthmatic patients. ninety seven consecutive patients with asthma and ninety healthy controls were included. all  patients  completed  a  short  form-36  health  sur...

asthma is one of the most common chronic diseases of childhood. inhaled corticosteroids (ics) are the recommended controller drug for asthma treatment. the aim of our study was to determine concerns and fears of parents of children with asthma towards the use of ics. one hundred parents of asthmatic children were interviewed using structural questionnaire. airway inflammation was reported by on...