objective: multiple myeloma (mm) is a plasma cell malignancy where plasma cells are increased in the bone marrow (bm) and usually do not enter peripheral blood, but produce harmful factors creating problems in these patients (e.g. malignant plasma cells over activate osteoclasts and inhibit osteoblasts with factors like rankl and dkk). these factors are a main cause of bone lesion in mm patient...

This paper investigated the porcine surfactant protein A (pSP-A) immunogenicity in murine model. Many elegant studies about SP-A therapeutic applications are available however specific studies about its exogenous immunogenicity were not easily assumed. Therefore, we investigated the immunogenicity of this porcine protein in mice. The mice received pSP-A subcutaneously on days 0 and 7. The anima...

background: it has been shown that zinc has an effect on physiological responses in animals and birds. on the other hand, dietary phytase in poultry results in increased availability of zinc. objectives: this study was conducted to investigate the effects of zinc oxide (zno) and escherichia coli-derived 6-phytase supplemented diets on the plasma metabolites and enzyme activities of broiler bree...

to estimate the effect of microencapsulated fish oil on blood metabolites, rumen and blood plasma fatty acids concentrations twelve sannan dairy goats with 30 ± 5 days in milk (dim) were allocated to 3 treatments in a 3×2 change over design with 2 periods of 30 days. treatments were: 1) the control (without fish oil), 2) microencapsulated fish oil (2% fish oil capsulated in 6% treated whey prot...

Generally, plasma proteins owe their binding capacity to the presence of aminoacid units which enter into intra- and intermolecular hydrophobic bonding with a diverse range of endo- and exogenous chemical substances. The intermolecular interactions between the hydrophobic areas of drug molecules and those of plasma proteins play an important role in drug-macromolecular complex formation and...

Intracranial artery stenosis, especially middle cerebral artery stenosis (MCAS), is prevalent in the Chinese population. Currently, few approaches target evaluating MCAS-associated plaque vulnerability. Herein we aimed to explore potential plasma biomarkers for vulnerable plaque in patients with MCAS. A total of 81 subjects who received microembolic signal (MES) detection were enrolled between ...